PMID- 10224040
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 19
DP  - 1999 May 7
TI  - Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that
      activates NF-kappaB.
PG  - 12955-8
AB  - The nematode CED-4 protein and its human homolog Apaf-1 play a central role in
      apoptosis by functioning as direct activators of death-inducing caspases. A novel
      human CED-4/Apaf-1 family member called CARD4 was identified that has a domain
      structure strikingly similar to the cytoplasmic, receptor-like proteins that
      mediate disease resistance in plants. CARD4 interacted with the serine-threonine 
      kinase RICK and potently induced NF-kappaB activity through TRAF-6 and NIK
      signaling molecules. In addition, coexpression of CARD4 augmented
      caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappaB and
      apoptotic signaling pathways and may be a component of the host innate immune
      response.
FAU - Bertin, J
AU  - Bertin J
AD  - Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
      bertin@mpi.com
FAU - Nir, W J
AU  - Nir WJ
FAU - Fischer, C M
AU  - Fischer CM
FAU - Tayber, O V
AU  - Tayber OV
FAU - Errada, P R
AU  - Errada PR
FAU - Grant, J R
AU  - Grant JR
FAU - Keilty, J J
AU  - Keilty JJ
FAU - Gosselin, M L
AU  - Gosselin ML
FAU - Robison, K E
AU  - Robison KE
FAU - Wong, G H
AU  - Wong GH
FAU - Glucksmann, M A
AU  - Glucksmann MA
FAU - DiStefano, P S
AU  - DiStefano PS
LA  - eng
SI  - GENBANK/AF126484
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (APAF1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Apoptotic Protease-Activating Factor 1)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Ced-4 protein, C elegans)
RN  - 0 (DNA, Complementary)
RN  - 0 (Helminth Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (NOD1 protein, human)
RN  - 0 (Nod1 Signaling Adaptor Protein)
RN  - 0 (Proteins)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - *Apoptosis
MH  - Apoptotic Protease-Activating Factor 1
MH  - Base Sequence
MH  - *Caenorhabditis elegans Proteins
MH  - Calcium-Binding Proteins/*metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - DNA, Complementary
MH  - Helminth Proteins/*metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - NF-kappa B/*metabolism
MH  - Nod1 Signaling Adaptor Protein
MH  - Proteins/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
EDAT- 1999/05/01 00:00
MHDA- 1999/05/01 00:01
CRDT- 1999/05/01 00:00
PHST- 1999/05/01 00:00 [pubmed]
PHST- 1999/05/01 00:01 [medline]
PHST- 1999/05/01 00:00 [entrez]
AID - 10.1074/jbc.274.19.12955 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 May 7;274(19):12955-8. doi: 10.1074/jbc.274.19.12955.