PMID- 10220430
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 9
DP  - 1999 Apr 27
TI  - Conservation of sequence and structure flanking the mouse and human beta-globin
      loci: the beta-globin genes are embedded within an array of odorant receptor
      genes.
PG  - 5129-34
AB  - In mouse and human, the beta-globin genes reside in a linear array that is
      associated with a positive regulatory element located 5' to the genes known as
      the locus control region (LCR). The sequences of the mouse and human beta-globin 
      LCRs are homologous, indicating conservation of an essential function in
      beta-globin gene regulation. We have sequenced regions flanking the beta-globin
      locus in both mouse and human and found that homology associated with the LCR is 
      more extensive than previously known, making up a conserved block of
      approximately 40 kb. In addition, we have identified DNaseI-hypersensitive sites 
      within the newly sequenced regions in both mouse and human, and these structural 
      features also are conserved. Finally, we have found that both mouse and human
      beta-globin loci are embedded within an array of odorant receptor genes that are 
      expressed in olfactory epithelium, and we also identify an olfactory receptor
      gene located 3' of the beta-globin locus in chicken. The data demonstrate an
      evolutionarily conserved genomic organization for the beta-globin locus and
      suggest a possible role for the beta-globin LCR in control of expression of these
      odorant receptor genes and/or the presence of mechanisms to separate regulatory
      signals in different tissues.
FAU - Bulger, M
AU  - Bulger M
AD  - Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview
      Avenue North, Seattle, WA 98109, USA.
FAU - van Doorninck, J H
AU  - van Doorninck JH
FAU - Saitoh, N
AU  - Saitoh N
FAU - Telling, A
AU  - Telling A
FAU - Farrell, C
AU  - Farrell C
FAU - Bender, M A
AU  - Bender MA
FAU - Felsenfeld, G
AU  - Felsenfeld G
FAU - Axel, R
AU  - Axel R
FAU - Groudine, M
AU  - Groudine M
LA  - eng
SI  - GENBANK/AF071080
SI  - GENBANK/AF133300
SI  - GENBANK/AF137131
SI  - GENBANK/AF137396
GR  - R37 DK044746/DK/NIDDK NIH HHS/United States
GR  - DK44746/DK/NIDDK NIH HHS/United States
GR  - DK52854/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Receptors, Odorant)
RN  - 9004-22-2 (Globins)
SB  - IM
EIN - Proc Natl Acad Sci U S A 1999 Jul 6;96(14):8307. von Doorninck JH [corrected to
      van Doorninck JH]
MH  - Animals
MH  - *Conserved Sequence
MH  - Gene Expression Regulation
MH  - Globins/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Receptors, Odorant/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
PMC - PMC21828
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - 10.1073/pnas.96.9.5129 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5129-34. doi: 10.1073/pnas.96.9.5129.