PMID- 10220376
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 9
DP  - 1999 Apr 27
TI  - Identification of a photoreceptor cell-specific nuclear receptor.
PG  - 4814-9
AB  - Nuclear receptors comprise a large and expanding family of transcription factors 
      involved in diverse aspects of animal physiology and development, the functions
      of which can be modulated in a spatial and temporal manner by access to small
      lipophilic ligands and/or the specificity of their own localized expression. Here
      we report the identification of a human nuclear receptor that reveals a unique
      proximal box (CNGCSG) in the DNA-binding domain. The conservation of this feature
      in its nematode counterpart suggests the requirement for this type of P box in
      the genetic cascades mediated by nuclear receptors in a wide variety of animal
      species. The expression of this receptor, PNR (photoreceptor-specific nuclear
      receptor), appears strongly restricted in the retina, exclusively in
      photoreceptor cells. In human cell lines, PNR expression was observed in Y79
      retinoblastoma along with other photoreceptor marker genes such as CRX. Among
      vertebrate receptors, PNR shares structural kinship with an orphan receptor TLX, 
      and despite distinct differences in the DNA binding domain, PNR is able to
      recognize a subset of TLX target sequences in vitro. Analyses of the human PNR
      gene revealed its chromosomal position as 15q24, a site that has recently been
      reported as a susceptible region for retinal degeneration. These data support a
      role for PNR in the regulation of signalling pathways intrinsic to the
      photoreceptor cell function.
FAU - Kobayashi, M
AU  - Kobayashi M
AD  - Graduate School of Biological Sciences, Nara Institute of Science and Technology,
      Ikoma, Nara 630-0101, Japan.
FAU - Takezawa, S
AU  - Takezawa S
FAU - Hara, K
AU  - Hara K
FAU - Yu, R T
AU  - Yu RT
FAU - Umesono, Y
AU  - Umesono Y
FAU - Agata, K
AU  - Agata K
FAU - Taniwaki, M
AU  - Taniwaki M
FAU - Yasuda, K
AU  - Yasuda K
FAU - Umesono, K
AU  - Umesono K
LA  - eng
SI  - GENBANK/AF121129
SI  - GENBANK/AF121130
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis/genetics
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - *Genome, Human
MH  - Humans
MH  - Molecular Sequence Data
MH  - Photoreceptor Cells, Vertebrate/*metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*genetics/metabolism
MH  - Sequence Alignment
PMC - PMC21774
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - 10.1073/pnas.96.9.4814 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4814-9. doi: 10.1073/pnas.96.9.4814.