PMID- 10220372
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 9
DP  - 1999 Apr 27
TI  - TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP
      family.
PG  - 4791-6
AB  - The TATA box-binding protein (TBP) is an essential component of the RNA
      polymerase II transcription apparatus in eukaryotic cells. Until recently, it was
      thought that the general transcriptional machinery was largely invariant and
      relied on a single TBP, whereas a large and diverse collection of activators and 
      repressors were primarily responsible for imparting specificity to transcription 
      initiation. However, it now appears that the "basal" transcriptional machinery
      also contributes to specificity via tissue-specific versions of TBP-associated
      factors as well as a tissue-specific TBP-related factor (TRF1) responsible for
      gene selectivity in Drosophila. Here we report the cloning of a TBP-related
      factor (TRF2) that is found in humans, Drosophila, Caenorhabditis elegans, and
      other metazoans. Like TRF1 and TBP, TRF2 binds transcription factor IIA (TFIIA)
      and TFIIB and appears to be part of a larger protein complex. TRF2's primary
      amino acid structure suggests divergence in the putative DNA binding domain, and 
      not surprisingly, it fails to bind to DNA containing canonical TATA boxes. Most
      importantly, TRF2 is associated with loci on Drosophila chromosomes distinct from
      either TBP or TRF1, so it may have different promoter specificity and regulate a 
      select subset of genes. These findings suggest that metazoans have evolved
      multiple TBPs to accommodate the vast increase in genes and expression patterns
      during development and cellular differentiation.
FAU - Rabenstein, M D
AU  - Rabenstein MD
AD  - Department of Molecular and Cell Biology, Howard Hughes Medical Institute,
      University of California, Berkeley, CA 94720-3204, USA.
FAU - Zhou, S
AU  - Zhou S
FAU - Lis, J T
AU  - Lis JT
FAU - Tjian, R
AU  - Tjian R
LA  - eng
SI  - GENBANK/AF136569
SI  - GENBANK/AF136570
GR  - GM25232/GM/NIGMS NIH HHS/United States
GR  - R37 CA025417/CA/NCI NIH HHS/United States
GR  - R37 GM025232/GM/NIGMS NIH HHS/United States
GR  - CA25417/CA/NCI NIH HHS/United States
GR  - R01 GM025232/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Telomeric Repeat Binding Protein 2)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila
MH  - Humans
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Analysis
MH  - *TATA Box
MH  - Telomeric Repeat Binding Protein 2
MH  - Transcription, Genetic
PMC - PMC21770
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - 10.1073/pnas.96.9.4791 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4791-6. doi: 10.1073/pnas.96.9.4791.