PMID- 10219263
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 40
IP  - 4
DP  - 1999 Apr
TI  - Characterization of seizures in the flathead rat: a new genetic model of epilepsy
      in early postnatal development.
PG  - 394-400
AB  - PURPOSE: Disorders in normal central nervous system (CNS) development are often
      associated with epilepsy. This report characterizes seizures in a novel genetic
      model of developmental epilepsy, the Flathead (FH) rat. METHODS: Animals (n = 76)
      ages P0-22 were monitored for clinical and electrographic seizure activity. The
      effects of various AEDs on seizure frequency and duration also were assessed:
      phenobarbital (PB; 40 mg/kg), valproate (VPA; 400 mg/kg), or ethosuximide (ESM;
      600 mg/kg). RESULTS: FHs display episodes of behavior characterized by whole-body
      tremor, strub tail, alternating forelimb clonus, and complete tonus. EEG
      recordings from neocortex reveal that FH seizures are bilateral and begin around 
      P7. Seizures occur at a frequency of approximately six per hour from P7 to P18
      and the average duration of seizures increases through development. PB, VPA, and 
      ESM failed to prevent seizures; however, PB significantly increased the interval 
      of seizures but had no effects on the duration of seizures, whereas VPA decreased
      the duration of seizures and not the interval. CONCLUSIONS: Seizures in FH rats
      occur at a constant and high frequency through a defined period in early
      postnatal development, and these seizures are not completely blocked by high
      doses of PB, VPA, or ESM. Because FH is a single-locus mutant displaying a highly
      regular pattern of seizure activity, it is an ideal model for examining the
      process of epileptogenesis in the developing brain, evaluating new AED therapies,
      and determining the identity of a gene essential to the normal development of
      cortical excitability.
FAU - Sarkisian, M R
AU  - Sarkisian MR
AD  - Department of Physiology and Neurobiology, University of Connecticut, Storrs
      06269, USA.
FAU - Rattan, S
AU  - Rattan S
FAU - D'Mello, S R
AU  - D'Mello SR
FAU - LoTurco, J J
AU  - LoTurco JJ
LA  - eng
GR  - HD20806/HD/NICHD NIH HHS/United States
GR  - MH56524/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 5SEH9X1D1D (Ethosuximide)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects/*growth & development/physiopathology
MH  - Cerebral Cortex/drug effects/growth & development/physiopathology
MH  - Disease Models, Animal
MH  - Electroencephalography/drug effects
MH  - Epilepsy/genetics/physiopathology
MH  - Ethosuximide/pharmacology
MH  - Female
MH  - Male
MH  - Models, Genetic
MH  - Mutation
MH  - Phenobarbital/pharmacology
MH  - Rats
MH  - Rats, Mutant Strains/*genetics
MH  - Rats, Wistar/genetics
MH  - Seizures/*genetics/physiopathology/prevention & control
MH  - Valproic Acid/pharmacology
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - 10.1111/j.1528-1157.1999.tb00732.x [doi]
PST - ppublish
SO  - Epilepsia. 1999 Apr;40(4):394-400. doi: 10.1111/j.1528-1157.1999.tb00732.x.