PMID- 10219242
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 2
DP  - 1999 Apr 16
TI  - A map of pheromone receptor activation in the mammalian brain.
PG  - 209-20
AB  - In mammals, the detection of pheromones is mediated by the vomeronasal system. We
      have employed gene targeting to visualize the pattern of projections of axons
      from vomeronasal sensory neurons in the accessory olfactory bulb. Neurons
      expressing a specific receptor project to multiple glomeruli that reside within
      spatially restricted domains. The formation of this sensory map in the accessory 
      olfactory bulb and the survival of vomeronasal organ sensory neurons require the 
      expression of pheromone receptors. In addition, we observe individual glomeruli
      in the accessory olfactory bulb that receive input from more than one type of
      sensory neuron. These observations indicate that the organization of the
      vomeronasal sensory afferents is dramatically different from that of the main
      olfactory system, and these differences have important implications for the logic
      of olfactory coding in the vomeronasal organ.
FAU - Belluscio, L
AU  - Belluscio L
AD  - Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical
      Institute, Columbia University, College of Physicians and Surgeons, New York, New
      York 10032, USA.
FAU - Koentges, G
AU  - Koentges G
FAU - Axel, R
AU  - Axel R
FAU - Dulac, C
AU  - Dulac C
LA  - eng
GR  - NS29832-07/NS/NINDS NIH HHS/United States
GR  - P01CA-23767-20A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA Primers)
SB  - IM
MH  - Animals
MH  - Axons/ultrastructure
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Brain Mapping
MH  - Chemoreceptor Cells/*metabolism
MH  - DNA Primers/genetics
MH  - Gene Targeting
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - Neural Pathways/anatomy & histology/metabolism
MH  - Neurons/cytology
MH  - Olfactory Bulb/anatomy & histology/metabolism
MH  - Olfactory Receptor Neurons/metabolism
MH  - Vomeronasal Organ/anatomy & histology/metabolism
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - S0092-8674(00)80731-X [pii]
AID - 10.1016/s0092-8674(00)80731-x [doi]
PST - ppublish
SO  - Cell. 1999 Apr 16;97(2):209-20. doi: 10.1016/s0092-8674(00)80731-x.