PMID- 10219241
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 2
DP  - 1999 Apr 16
TI  - Variable patterns of axonal projections of sensory neurons in the mouse
      vomeronasal system.
PG  - 199-208
AB  - The vomeronasal system mediates pheromonal effects in mammals. We have employed
      gene targeting technology to introduce mutations in a putative pheromone receptor
      gene, VR2, in the germline of mice. By generating alleles differentially tagged
      with the histological markers taulacZ and tauGFP, we show that VR2 is
      monoallelically expressed in a given neuron. Axons of VR2-expressing neurons
      converge onto numerous glomeruli in the accessory olfactory bulb. The pattern of 
      axonal projections is complex and variable. This wiring diagram is substantially 
      different from that of the main olfactory system. The projection pattern is
      disrupted by deleting the coding region of VR2, but an unrelated
      seven-transmembrane protein, the odorant receptor M71, can partially substitute
      for VR2.
FAU - Rodriguez, I
AU  - Rodriguez I
AD  - Rockefeller University, New York, New York 10021, USA.
FAU - Feinstein, P
AU  - Feinstein P
FAU - Mombaerts, P
AU  - Mombaerts P
LA  - eng
SI  - GENBANK/AF132114
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA Primers)
RN  - 0 (Luminescent Proteins)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Axons/metabolism/*ultrastructure
MH  - Base Sequence
MH  - Cell Count
MH  - Chemoreceptor Cells/metabolism
MH  - DNA Primers/genetics
MH  - Gene Expression
MH  - Gene Targeting
MH  - Germ-Line Mutation
MH  - Green Fluorescent Proteins
MH  - Heterozygote
MH  - Homozygote
MH  - Lac Operon
MH  - Luminescent Proteins/genetics
MH  - Mice
MH  - Mutagenesis, Site-Directed
MH  - Olfactory Receptor Neurons/metabolism/*ultrastructure
MH  - Rats
MH  - Vomeronasal Organ/metabolism/*ultrastructure
EDAT- 1999/04/29 00:00
MHDA- 1999/04/29 00:01
CRDT- 1999/04/29 00:00
PHST- 1999/04/29 00:00 [pubmed]
PHST- 1999/04/29 00:01 [medline]
PHST- 1999/04/29 00:00 [entrez]
AID - S0092-8674(00)80730-8 [pii]
AID - 10.1016/s0092-8674(00)80730-8 [doi]
PST - ppublish
SO  - Cell. 1999 Apr 16;97(2):199-208. doi: 10.1016/s0092-8674(00)80730-8.