PMID- 10217429
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 448
IP  - 1
DP  - 1999 Apr 1
TI  - Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene
      and its location in chromosome 19p13.11-13 locus.
PG  - 149-52
AB  - We have cloned earlier a short human genomic fragment which showed strong
      similarity with the mouse cDNA encoding lung Kruppel-like zinc finger
      transcription factor (LKLF), predominantly expressed in mouse developing lung,
      spleen, and vascular system, which might play a key role in programming the
      quiescent state of single positive T cells and blood vessel wall morphogenesis.
      Here we report the successful cloning of the human LKLF cDNA, its genomic
      structure and chromosomal localization at the 19p13.11-p13.13 locus. The
      full-length human LKLF cDNA has longer 5'-UTR with higher GC content than mouse
      cDNA and encodes a predicted protein of 355 amino acids which has three zinc
      fingers at the C-terminus and a proline-rich N-terminal domain. Human and mouse
      proteins share 87.3% identity and 90.2% amino acid similarity. The human LKLF
      gene consists of three exons. From the proximal promoter to the end of the second
      exon, we have found a CpG island with an average 76% GC content and two regions
      of unusually high GC density.
FAU - Kozyrev, S V
AU  - Kozyrev SV
AD  - Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow.
FAU - Hansen, L L
AU  - Hansen LL
FAU - Poltaraus, A B
AU  - Poltaraus AB
FAU - Domninsky, D A
AU  - Domninsky DA
FAU - Kisselev, L L
AU  - Kisselev LL
LA  - eng
SI  - GENBANK/AF123344
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA, Complementary)
RN  - 0 (KLF2 protein, human)
RN  - 0 (Klf2 protein, mouse)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - *CpG Islands
MH  - DNA, Complementary
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/*genetics
MH  - *Zinc Fingers
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - S0014-5793(99)00348-8 [pii]
AID - 10.1016/s0014-5793(99)00348-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Apr 1;448(1):149-52. doi: 10.1016/s0014-5793(99)00348-8.