PMID- 10217402
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 448
IP  - 1
DP  - 1999 Apr 1
TI  - Novel BNIP1 variants and their interaction with BCL2 family members.
PG  - 23-7
AB  - By PCR and EST database searches we have identified three novel BNIP1 splice
      variants, and found that one of them, BNIP1-b, contains a highly conserved BH3
      domain. The BNIP1 gene has been assigned to chromosome 5q33-34. Using in vitro
      protein-protein interaction assays, all BNIP1 variants were shown to interact
      with BCL2 and also with BCL2L1 (previously Bcl-xL). These interactions are
      BH3-independent. Furthermore, the BNIP1 variants cannot interact with BAX. The
      results suggest that the BNIP1 variants are novel members of the BCL2 family but 
      function through a mechanism different from other BH3-only members.
FAU - Zhang, H
AU  - Zhang H
AD  - Novartis Pharma AG, Oncology, Molecular Genetics, Basel, Switzerland.
      hzhang@uhbs.ch
FAU - Heim, J
AU  - Heim J
FAU - Meyhack, B
AU  - Meyhack B
LA  - eng
SI  - GENBANK/AF083078
SI  - GENBANK/AF083956
SI  - GENBANK/AF083957
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (BAX protein, human)
RN  - 0 (BCL2L1 protein, human)
RN  - 0 (BNIP1 protein, human)
RN  - 0 (DNA, Complementary)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 0 (bcl-X Protein)
SB  - IM
MH  - *Alternative Splicing
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - DNA, Complementary
MH  - Humans
MH  - Molecular Sequence Data
MH  - Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/genetics/*metabolism
MH  - bcl-2-Associated X Protein
MH  - bcl-X Protein
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - S0014-5793(99)00335-X [pii]
AID - 10.1016/s0014-5793(99)00335-x [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Apr 1;448(1):23-7. doi: 10.1016/s0014-5793(99)00335-x.