PMID- 10216276
OWN - NLM
STAT- MEDLINE
DCOM- 19990602
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1438
IP  - 1
DP  - 1999 Apr 19
TI  - Signalling sphingomyelinases: which, where, how and why?
PG  - 1-17
AB  - A major lipid signalling pathway in mammalian cells implicates the activation of 
      sphingomyelinase (SMase), which upon cell stimulation hydrolyses the ubiquitous
      sphingophospholipid sphingomyelin to ceramide. This review summarizes our current
      knowledge on the nature and regulation of signalling SMase(s). Because of the
      controversy on the identity of this(these) phospholipase(s), the roles of various
      SMases in cell signalling are discussed. Special attention is also given to the
      subcellular site of action of signalling SMases and to the cellular factors that 
      positively or negatively control their activity. These regulating agents include 
      lipids (arachidonic acid, diacylglycerol and ceramide), kinases, proteases,
      glutathione and other proteins.
FAU - Levade, T
AU  - Levade T
AD  - INSERM Unit 466, Laboratoire de Biochimie, Maladies Metaboliques, Institut Louis 
      Bugnard, Bat. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhes, E 9910, Toulouse Cedex 
      4, France. levade@rangueil.inserm.fr
FAU - Jaffrezou, J P
AU  - Jaffrezou JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Ceramides)
RN  - 0 (Sphingomyelins)
RN  - EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Cells, Cultured
MH  - Ceramides/metabolism
MH  - Enzyme Activation
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Signal Transduction
MH  - Sphingomyelin Phosphodiesterase/biosynthesis/*metabolism
MH  - Sphingomyelins/metabolism
RF  - 186
EDAT- 1999/04/27 00:00
MHDA- 1999/04/27 00:01
CRDT- 1999/04/27 00:00
PHST- 1999/04/27 00:00 [pubmed]
PHST- 1999/04/27 00:01 [medline]
PHST- 1999/04/27 00:00 [entrez]
AID - S1388-1981(99)00038-4 [pii]
AID - 10.1016/s1388-1981(99)00038-4 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Apr 19;1438(1):1-17. doi:
      10.1016/s1388-1981(99)00038-4.