PMID- 10215710
OWN - NLM
STAT- MEDLINE
DCOM- 19990604
LR  - 20220331
IS  - 0003-2409 (Print)
IS  - 0003-2409 (Linking)
VI  - 54
IP  - 2
DP  - 1999 Feb
TI  - alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic 
      role.
PG  - 146-65
AB  - Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic 
      practice as well as in chronic pain therapy because it has both anaesthetic and 
      analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, 
      dexmedetomidine and mivazerol, may also have a role in providing haemodynamic 
      stability in patients who are at risk of peri-operative ischaemia. The 
      side-effects of hypotension and bradycardia have limited the routine use of 
      alpha-2 adrenoceptor agonists. Investigations into the molecular pharmacology of 
      alpha-2 adrenoceptors have elucidated their role in the control of wakefulness, 
      blood pressure and antinociception. We discuss the pharmacology of alpha-2 
      adrenoceptors and their therapeutic role in this review. The alpha-2 adrenoceptor 
      agonists are agonists at imidazoline receptors which are involved in central 
      blood pressure control. Selective imidazoline agonists are now available for 
      clinical use as antihypertensive agents and their pharmacology is discussed.
FAU - Khan, Z P
AU  - Khan ZP
AD  - Department of Anaesthetics, Imperial College School of Medicine, St Mary's 
      Hospital, London, UK.
FAU - Ferguson, C N
AU  - Ferguson CN
FAU - Jones, R M
AU  - Jones RM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Imidazoles)
RN  - 0 (Imidazoline Receptors)
RN  - 0 (Receptors, Drug)
SB  - IM
MH  - Adjuvants, Anesthesia
MH  - *Adrenergic alpha-2 Receptor Agonists
MH  - Adrenergic alpha-Agonists/pharmacokinetics/*pharmacology
MH  - Analgesia/methods
MH  - Anesthesia/*methods
MH  - Animals
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Imidazoles/*pharmacokinetics
MH  - Imidazoline Receptors
MH  - Receptors, Drug/*agonists
RF  - 215
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - 10.1046/j.1365-2044.1999.00659.x [doi]
PST - ppublish
SO  - Anaesthesia. 1999 Feb;54(2):146-65. doi: 10.1046/j.1365-2044.1999.00659.x.