PMID- 10215164
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 90
IP  - 2
DP  - 1999 May
TI  - Alteration in expression of G-protein-activated inward rectifier K+-channel
      subunits GIRK1 and GIRK2 in the rat brain following electroconvulsive shock.
PG  - 621-7
AB  - G-protein-activated inward rectifier potassium channels are coupled to a number
      of neurotransmitter receptors, including some monoamine receptors. In the present
      study we have investigated the effect of electroconvulsive shock on gene
      expression of the G-protein-activated inward rectifier potassium channel subunits
      G-protein-coupled inward rectifier K+-channel (GIRK1) and GIRK2 in the rat brain 
      using in situ hybridization and immunocytochemistry. Acute electroconvulsive
      shock (a single shock) increased GIRK2 expression while causing a transient
      reduction of the messenger RNA abundance of GIRK1 in granule cells of the dentate
      gyrus. Chronic electroconvulsive shock (five shocks over 10 days) caused a larger
      increase in GIRK2 messenger RNA abundance, which was accompanied by an increase
      in GIRK2 immunoreactivity in the molecular layer of the dentate gyrus. Unlike for
      acute electroconvulsive shock, GIRK1 messenger RNA abundance in the dentate gyrus
      was significantly increased after chronic electroconvulsive shock. No significant
      alterations in GIRK1 and GIRK2 messenger RNA abundance were detected in the other
      brain regions studied, including the CA1 and CA3 subfields of the hippocampus,
      the frontal-parietal cortex and piriform cortex. The neuroanatomically specific
      changes in expression of the potassium channel subunits may directly influence
      neuronal excitability as well as the functions of G-protein-coupled
      neurotransmitter receptors.
FAU - Pei, Q
AU  - Pei Q
AD  - Oxford University-SmithKline Beecham Centre for Applied Neuropsychobiology,
      University Department of Clinical Pharmacology, Radcliffe Infirmary, UK.
FAU - Lewis, L
AU  - Lewis L
FAU - Grahame-Smith, D G
AU  - Grahame-Smith DG
FAU - Zetterstrom, T S
AU  - Zetterstrom TS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (G Protein-Coupled Inwardly-Rectifying Potassium Channels)
RN  - 0 (Potassium Channels)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (RNA, Messenger)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - *Electroshock
MH  - G Protein-Coupled Inwardly-Rectifying Potassium Channels
MH  - GTP-Binding Proteins/*metabolism
MH  - *Gene Expression Regulation
MH  - Hippocampus/metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Organ Specificity
MH  - Parietal Lobe/metabolism
MH  - Potassium Channels/analysis/*genetics
MH  - *Potassium Channels, Inwardly Rectifying
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Transcription, Genetic
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0306-4522(98)00453-9 [pii]
AID - 10.1016/s0306-4522(98)00453-9 [doi]
PST - ppublish
SO  - Neuroscience. 1999 May;90(2):621-7. doi: 10.1016/s0306-4522(98)00453-9.