PMID- 10214955
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 447
IP  - 2-3
DP  - 1999 Mar 26
TI  - Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p.
PG  - 247-50
AB  - The Sec23p-Sec24p complex is a component of COPII-coated vesicles that mediate
      protein transport from the endoplasmic reticulum in yeast. The mammalian
      hypothetical protein KIAA0079 (KIAA0079p) exhibits sequence similarity to yeast
      Sec24p. KIAA0079p was co-eluted with mammalian Sec23p on gel filtration. In vitro
      binding experiments revealed that the C-terminal region of KIAA0079p binds to the
      N-terminal region of mammalian Sec23p. Overexpression of KIAA0079p caused a
      defect in protein export from the endoplasmic reticulum. These results support
      the idea that KIAA0079p is a functional homologue of yeast Sec24p.
FAU - Tani, K
AU  - Tani K
AD  - School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, 
      Japan.
FAU - Oyama, Y
AU  - Oyama Y
FAU - Hatsuzawa, K
AU  - Hatsuzawa K
FAU - Tagaya, M
AU  - Tagaya M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Fungal Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (SEC23A protein, human)
RN  - 0 (SEC24 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Vesicular Transport Proteins)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Biological Transport, Active
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - Endoplasmic Reticulum/metabolism
MH  - Fungal Proteins/chemistry/genetics/*metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Membrane Proteins/chemistry/genetics/*metabolism
MH  - Proteins/chemistry/isolation & purification/metabolism
MH  - Saccharomyces cerevisiae/genetics/metabolism
MH  - *Saccharomyces cerevisiae Proteins
MH  - Transfection
MH  - Vero Cells
MH  - Vesicular Transport Proteins
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0014-5793(99)00303-8 [pii]
AID - 10.1016/s0014-5793(99)00303-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Mar 26;447(2-3):247-50. doi: 10.1016/s0014-5793(99)00303-8.