PMID- 10214944
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 447
IP  - 2-3
DP  - 1999 Mar 26
TI  - Accelerated filament formation from tau protein with specific FTDP-17 missense
      mutations.
PG  - 195-9
AB  - Tau is the major component of the neurofibrillar tangles that are a pathological 
      hallmark of Alzheimers' disease. The identification of missense and splicing
      mutations in tau associated with the inherited frontotemporal dementia and
      Parkinsonism linked to chromosome 17 demonstrated that tau dysfunction can cause 
      neurodegeneration. However, the mechanism by which tau dysfunction leads to
      neurodegeneration remains uncertain. Here, we present evidence that
      frontotemporal dementia and Parkinsonism linked to chromosome 17 missense
      mutations, P301L, V337M and R406W, cause an accelerated aggregation of tau into
      filaments. These results suggest one mechanism by which these mutations can cause
      neurodegeneration and frontotemporal dementia and Parkinsonism linked to
      chromosome 17.
FAU - Nacharaju, P
AU  - Nacharaju P
AD  - Department of Pharmacology, Mayo Clinic Jacksonville, FL 32224, USA.
FAU - Lewis, J
AU  - Lewis J
FAU - Easson, C
AU  - Easson C
FAU - Yen, S
AU  - Yen S
FAU - Hackett, J
AU  - Hackett J
FAU - Hutton, M
AU  - Hutton M
FAU - Yen, S H
AU  - Yen SH
LA  - eng
GR  - AG01136/AG/NIA NIH HHS/United States
GR  - NS37143/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Biopolymers)
RN  - 0 (DNA Primers)
RN  - 0 (Recombinant Proteins)
RN  - 0 (tau Proteins)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Alzheimer Disease/genetics/metabolism
MH  - Arachidonic Acid/pharmacology
MH  - Base Sequence
MH  - Biopolymers/chemistry/genetics/metabolism
MH  - Chromosomes, Human, Pair 17/genetics
MH  - DNA Primers/genetics
MH  - Dementia/genetics
MH  - Genetic Linkage
MH  - Heparin/pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - Microscopy, Electron
MH  - *Mutation, Missense
MH  - Nerve Degeneration/genetics
MH  - Neurofibrillary Tangles/metabolism
MH  - Parkinson Disease/genetics
MH  - Recombinant Proteins/genetics/metabolism/ultrastructure
MH  - tau Proteins/*genetics/*metabolism/ultrastructure
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0014-5793(99)00294-X [pii]
AID - 10.1016/s0014-5793(99)00294-x [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Mar 26;447(2-3):195-9. doi: 10.1016/s0014-5793(99)00294-x.