PMID- 10214908
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190822
IS  - 0300-9084 (Print)
IS  - 0300-9084 (Linking)
VI  - 81
IP  - 1-2
DP  - 1999 Jan-Feb
TI  - DNA damage recognition during nucleotide excision repair in mammalian cells.
PG  - 39-44
AB  - For the bulk of mammalian DNA, the core protein factors needed for damage
      recognition and incision during nucleotide excision repair (NER) are the XPA
      protein, the heterotrimeric RPA protein, the 6 to 9-subunit TFIIH, the XPC-hHR23B
      complex, the XPG nuclease, and the ERCC1-XPF nuclease. With varying efficiencies,
      NER can repair a very wide range of DNA adducts, from bulky helical distortions
      to subtle modifications on sugar residues. Several of the NER factors have an
      affinity for damaged DNA. The strongest binding factor appears to be XPC-hHR23B
      but preferential binding to damage is also a property of XPA, RPA, and components
      of TFIIH. It appears that in order to be repaired by NER, an adduct in DNA must
      have two features: it must create a helical distortion, and there must be a
      change in DNA chemistry. Initial recognition of the distortion is the most likely
      function for XPC-hHR23B and perhaps XPA and RPA, whereas TFIIH is well-suited to 
      locate the damaged DNA strand by locating altered DNA chemistry that blocks
      translocation of the XPB and XPD components.
FAU - Wood, R D
AU  - Wood RD
AD  - Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Xeroderma Pigmentosum Group A Protein)
SB  - IM
MH  - Animals
MH  - *DNA Damage
MH  - *DNA Repair
MH  - DNA-Binding Proteins/metabolism
MH  - Mammals
MH  - Models, Chemical
MH  - Xeroderma Pigmentosum Group A Protein
RF  - 52
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0300-9084(99)80036-4 [pii]
AID - 10.1016/s0300-9084(99)80036-4 [doi]
PST - ppublish
SO  - Biochimie. 1999 Jan-Feb;81(1-2):39-44. doi: 10.1016/s0300-9084(99)80036-4.