PMID- 10213461
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20071115
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 19
IP  - 3
DP  - 1999 Mar
TI  - Organization of the chemokine gene cluster on human chromosome 17q11.2 containing
      the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES.
PG  - 227-34
AB  - To understand the organization of the human CC chemokine gene cluster on
      chromosome 17q11.2, we determined the nucleotide sequence of a region 181 kb long
      containing five CC chemokine genes, MPIF-1 (SCYA23), HCC-2 (SCYA15), HCC-1
      (SCYA14), LEC (SCYA16), and RANTES (SCYA5), by the random shot-gun method. The
      four CC chemokine genes, MPIF-1, HCC-2, HCC-1, and LEC, are clustered within a
      region 40 kb long, whereas the RANTES gene is located approximately 10 kb apart
      from the four chemokine gene minicluster. These chemokine genes are arranged in
      the same orientation, and their sizes are relatively long, 3.1 (HCC-1)-8.8 kb
      (RANTES) when compared with other CC chemokine genes, such as
      MIP-1alpha/LD78alpha (SCYA3) (1.9 kb) and MCP-1 (SCYA2) (1.5 kb). In contrast to 
      most other human CC chemokine genes that consist of three exons, the MPIF-1 and
      HCC-2 genes, separated by 12 kb, have four exons. When the nucleotide sequences
      of the MPIF-1 and HCC-2 genes are compared, they are well conserved, including
      introns and flanking sequences, except for the middle region of the long first
      intron, indicating that they have been generated recently in evolutionary terms
      by duplication. In addition to the CC chemokine genes, more than 30 exons are
      identified in the sequenced region by similarity search against expressed
      sequence tags (ESTs) and also by the gene prediction program GenScan. This
      indicates that the chemokine cluster sequenced in this study is a gene-rich
      region in the human genome.
FAU - Nomiyama, H
AU  - Nomiyama H
AD  - Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan.
      nomiyama@gpo.kumamoto-u.ac.jp
FAU - Fukuda, S
AU  - Fukuda S
FAU - Iio, M
AU  - Iio M
FAU - Tanase, S
AU  - Tanase S
FAU - Miura, R
AU  - Miura R
FAU - Yoshie, O
AU  - Yoshie O
LA  - eng
SI  - GENBANK/AF002482
SI  - GENBANK/AF003976
SI  - GENBANK/AF088219
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (CCL14 protein, human)
RN  - 0 (CCL15 protein, human)
RN  - 0 (CCL16 protein, human)
RN  - 0 (CCL23 protein, human)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines, CC)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Monokines)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chemokine CCL5/genetics
MH  - Chemokines, CC/*genetics
MH  - *Chromosomes, Human, Pair 17
MH  - Cloning, Molecular
MH  - Humans
MH  - Macrophage Inflammatory Proteins
MH  - Molecular Sequence Data
MH  - *Monokines
MH  - *Multigene Family
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
EDAT- 1999/04/23 00:00
MHDA- 1999/04/23 00:01
CRDT- 1999/04/23 00:00
PHST- 1999/04/23 00:00 [pubmed]
PHST- 1999/04/23 00:01 [medline]
PHST- 1999/04/23 00:00 [entrez]
AID - 10.1089/107999099314153 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1999 Mar;19(3):227-34. doi: 10.1089/107999099314153.