PMID- 10212285
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 18
DP  - 1999 Apr 30
TI  - The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high 
      levels in reproductive tissues.
PG  - 12939-44
AB  - We have reported in this paper the complete cDNA sequence, gene structure, and
      tissue-specific expression of LOXL2, a new amine oxidase and a member of an
      emerging family of human lysyl oxidases. The predicted amino acid sequence, from 
      several overlapping cDNA clones isolated from placenta and spleen cDNA libraries,
      shared extensive sequence homology with the conserved copper-binding and
      catalytic domains of both lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL)
      protein. These conserved domains are encoded by five consecutive exons within the
      LOX, LOXL, and LOXL2 genes that also maintained exon-intron structure
      conservation. In contrast, six exons encoding the amino-terminal domains diverged
      both in sequence and structure. Exon 1 of the LOXL2 gene does not encode a signal
      sequence that is present in LOX and LOXL, suggesting a different processing and
      intracellular localization for this new protein. Expression of the LOXL2 gene was
      detected in almost all tissues with the highest steady state mRNA levels in the
      reproductive tissues, placenta, uterus and prostate. In situ hybridization
      identified placental syncytial and cytotrophoblasts responsible for the synthesis
      of LOXL2 mRNA and demonstrated a spatial and temporal expression pattern unique
      to the LOXL2 gene.
FAU - Jourdan-Le Saux, C
AU  - Jourdan-Le Saux C
AD  - Pacific Biomedical Research Center, University of Hawaii, Honolulu, Hawaii 96822,
      USA.
FAU - Tronecker, H
AU  - Tronecker H
FAU - Bogic, L
AU  - Bogic L
FAU - Bryant-Greenwood, G D
AU  - Bryant-Greenwood GD
FAU - Boyd, C D
AU  - Boyd CD
FAU - Csiszar, K
AU  - Csiszar K
LA  - eng
SI  - GENBANK/AF117949
SI  - GENBANK/AF117950
GR  - CA766580/CA/NCI NIH HHS/United States
GR  - HD24314/HD/NICHD NIH HHS/United States
GR  - RR03061/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
RN  - EC 1.4.3.- (LOXL2 protein, human)
SB  - IM
MH  - Amino Acid Oxidoreductases/*genetics
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Exons
MH  - *Gene Expression
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Placenta/*enzymology
MH  - Promoter Regions, Genetic
MH  - Transcription, Genetic
EDAT- 1999/04/23 00:00
MHDA- 1999/04/23 00:01
CRDT- 1999/04/23 00:00
PHST- 1999/04/23 00:00 [pubmed]
PHST- 1999/04/23 00:01 [medline]
PHST- 1999/04/23 00:00 [entrez]
AID - 10.1074/jbc.274.18.12939 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Apr 30;274(18):12939-44. doi: 10.1074/jbc.274.18.12939.