PMID- 10212244
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20190816
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 18
DP  - 1999 Apr 30
TI  - Characterization of a novel type of serine/threonine kinase that specifically
      phosphorylates the human goodpasture antigen.
PG  - 12642-9
AB  - Goodpasture disease is an autoimmune disorder that occurs naturally only in
      humans. Also exclusive to humans is the phosphorylation process that targets the 
      unique N-terminal region of the Goodpasture antigen. Here we report the molecular
      cloning of GPBP (Goodpasture antigen-binding protein), a previously unknown
      624-residue polypeptide. Although the predicted sequence does not meet the
      conventional structural requirements for a protein kinase, its recombinant
      counterpart specifically binds to and phosphorylates the exclusive N-terminal
      region of the human Goodpasture antigen in vitro. This novel kinase is widely
      expressed in human tissues but shows preferential expression in the histological 
      structures that are targets of common autoimmune responses. The work presented in
      this report highlights a novel gene to be explored in human autoimmunity.
FAU - Raya, A
AU  - Raya A
AD  - Fundacion Valenciana de Investigaciones Biomedicas, Instituto de Investigaciones 
      Citologicas, 46010 Valencia, Spain.
FAU - Revert, F
AU  - Revert F
FAU - Navarro, S
AU  - Navarro S
FAU - Saus, J
AU  - Saus J
LA  - eng
SI  - GENBANK/AF136450
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Autoantigens)
RN  - 0 (Collagen Type IV)
RN  - 0 (type IV collagen alpha3 chain)
RN  - 9007-34-5 (Collagen)
RN  - EC 2.7.1.- (CERT1 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Autoantigens/chemistry/*metabolism
MH  - Base Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Collagen/chemistry/*metabolism
MH  - *Collagen Type IV
MH  - Humans
MH  - Immunohistochemistry
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein Biosynthesis
MH  - Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism
MH  - Saccharomyces cerevisiae/genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/04/23 00:00
MHDA- 1999/04/23 00:01
CRDT- 1999/04/23 00:00
PHST- 1999/04/23 00:00 [pubmed]
PHST- 1999/04/23 00:01 [medline]
PHST- 1999/04/23 00:00 [entrez]
AID - 10.1074/jbc.274.18.12642 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Apr 30;274(18):12642-9. doi: 10.1074/jbc.274.18.12642.