PMID- 10211996
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20061115
IS  - 0023-6837 (Print)
IS  - 0023-6837 (Linking)
VI  - 79
IP  - 4
DP  - 1999 Apr
TI  - Differential expression of frpHE: a novel human stromal protein of the secreted
      frizzled gene family, during the endometrial cycle and malignancy.
PG  - 439-47
AB  - By using the differential display technique to identify genes that are
      differentially expressed in human endometrial carcinoma compared with normal
      endometrium, we have cloned frpHE, a novel member of the secreted frizzled gene
      family. By in situ hybridization, we have determined that frpHE is expressed by
      mesenchymal cells but not by epithelial cells. The expression of frpHE is
      modulated during the endometrial cycle: it is expressed in the stroma of
      proliferative endometrium and not significantly detectable in secretory or
      menstrual endometrium, suggesting that frpHE is under hormonal regulation. In
      addition, the expression of frpHE mRNA is markedly up-regulated in the stroma of 
      endometrial hyperplasia and carcinoma and in the stroma of in situ and
      infiltrating breast carcinomas. Injection of frpHE mRNA in Xenopus embryos
      inhibited the Wnt-8 mediated dorsal axis duplication. These results indicate that
      frpHE functions as a regulator of the Wnt-frizzled signaling pathway and is
      involved in endometrial physiology and carcinogenesis.
FAU - Abu-Jawdeh, G
AU  - Abu-Jawdeh G
AD  - Department of Pathology, Beth Israel-Deaconess Medical Center and Harvard Medical
      School, Boston, Massachusetts 02215, USA.
FAU - Comella, N
AU  - Comella N
FAU - Tomita, Y
AU  - Tomita Y
FAU - Brown, L F
AU  - Brown LF
FAU - Tognazzi, K
AU  - Tognazzi K
FAU - Sokol, S Y
AU  - Sokol SY
FAU - Kocher, O
AU  - Kocher O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Invest
JT  - Laboratory investigation; a journal of technical methods and pathology
JID - 0376617
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (SFRP4 protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blastomeres/physiology
MH  - Breast/cytology/metabolism/pathology
MH  - Breast Neoplasms/metabolism/pathology
MH  - Cloning, Molecular
MH  - Embryo, Nonmammalian/physiology
MH  - Endometrial Neoplasms/genetics/*metabolism/pathology
MH  - Endometrium/cytology/*metabolism/pathology
MH  - Epithelial Cells/cytology/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Mesoderm/cytology/metabolism/pathology
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Organ Specificity
MH  - Proto-Oncogene Proteins/biosynthesis/chemistry/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Stromal Cells/cytology/*metabolism/pathology
MH  - Transcription, Genetic
MH  - Xenopus laevis
EDAT- 1999/04/22 00:00
MHDA- 1999/04/22 00:01
CRDT- 1999/04/22 00:00
PHST- 1999/04/22 00:00 [pubmed]
PHST- 1999/04/22 00:01 [medline]
PHST- 1999/04/22 00:00 [entrez]
PST - ppublish
SO  - Lab Invest. 1999 Apr;79(4):439-47.