PMID- 10211827
OWN - NLM
STAT- MEDLINE
DCOM- 19990714
LR  - 20181113
IS  - 0961-8368 (Print)
IS  - 0961-8368 (Linking)
VI  - 8
IP  - 4
DP  - 1999 Apr
TI  - Structural and phylogenetic characterization of human SLURP-1, the first secreted
      mammalian member of the Ly-6/uPAR protein superfamily.
PG  - 810-9
AB  - Members of the Ly-6/uPAR protein family share one or several repeat units of the 
      Ly-6/uPAR domain that is defined by a distinct disulfide bonding pattern between 
      8 or 10 cysteine residues. The Ly-6/uPAR protein family can be divided into two
      subfamilies. One comprises GPI-anchored glycoprotein receptors with 10 cysteine
      residues. The other subfamily includes the secreted single-domain snake and frog 
      cytotoxins, and differs significantly in that its members generally possess only 
      eight cysteines and no GPI-anchoring signal sequence. We report the purification 
      and structural characterization of human SLURP-1 (secreted mammalian Ly-6/uPAR
      related protein 1) from blood and urine peptide libraries. SLURP-1 is encoded by 
      the ARS (component B)-81/s locus, and appears to be the first mammalian member of
      the Ly-6/uPAR family lacking a GPI-anchoring signal sequence. A phylogenetic
      analysis based on the SLURP-1 primary protein structure revealed a closer
      relationship to the subfamily of cytotoxins. Since the SLURP-1 gene maps to the
      same chromosomal region as several members of the Ly-6/uPAR subfamily of
      glycoprotein receptors, it is suggested that both biologically distinct
      subfamilies might have co-evolved from local chromosomal duplication events.
FAU - Adermann, K
AU  - Adermann K
AD  - Lower Saxony Institute for Peptide Research (IPF), Hannover, Germany.
FAU - Wattler, F
AU  - Wattler F
FAU - Wattler, S
AU  - Wattler S
FAU - Heine, G
AU  - Heine G
FAU - Meyer, M
AU  - Meyer M
FAU - Forssmann, W G
AU  - Forssmann WG
FAU - Nehls, M
AU  - Nehls M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Protein Sci
JT  - Protein science : a publication of the Protein Society
JID - 9211750
RN  - 0 (Antigens, Ly)
RN  - 0 (Cytotoxins)
RN  - 0 (Peptide Library)
RN  - 0 (SLURP1 protein, human)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Animals
MH  - Antigens, Ly/blood/*chemistry/urine
MH  - Anura
MH  - Cytotoxins/chemistry
MH  - Humans
MH  - Mass Spectrometry
MH  - Peptide Library
MH  - *Phylogeny
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Snakes
MH  - Time Factors
MH  - Urokinase-Type Plasminogen Activator/blood/*chemistry/urine
PMC - PMC2144295
EDAT- 1999/04/22 00:00
MHDA- 1999/04/22 00:01
CRDT- 1999/04/22 00:00
PHST- 1999/04/22 00:00 [pubmed]
PHST- 1999/04/22 00:01 [medline]
PHST- 1999/04/22 00:00 [entrez]
AID - 10.1110/ps.8.4.810 [doi]
PST - ppublish
SO  - Protein Sci. 1999 Apr;8(4):810-9. doi: 10.1110/ps.8.4.810.