PMID- 10210434
OWN - NLM
STAT- MEDLINE
DCOM- 19990518
LR  - 20071114
IS  - 0022-5347 (Print)
IS  - 0022-5347 (Linking)
VI  - 161
IP  - 5
DP  - 1999 May
TI  - Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate
      development.
PG  - 1655-61
AB  - The role of Hoxa-13 in postnatal morphogenesis of the male accessory sex organs
      was assessed by correlating the Hoxa-13 expression domain with phenotypic
      abnormalities in heterozygous Hypodactyly mutants. Hypodactyly is a naturally
      occurring semi-dominant mutation that results from a 50-base pair deletion in
      exon one of the Hoxa-13 allele. We demonstrate that Hoxa-13 is broadly expressed 
      in the developing lower genitourinary tract and that the Hypodactyly mutation
      results in a specific phenotype characterized by decreased size and branching of 
      the dorsolateral and ventral prostate and abnormal seminal vesicle morphology.
      This phenotype partially overlaps the genitourinary phenotype observed in Hoxd-13
      deficient mice and comparison showed similar domains of Hoxa-13 and Hoxd-13
      expression in the lower genitourinary tract. The similarity in expression and
      overlap in phenotype resulting from mutation is consistent with additive function
      and partial functional redundancy of Hoxa-13 and Hoxd-13 in male accessory sex
      organ development.
FAU - Podlasek, C A
AU  - Podlasek CA
AD  - Department of Urology, Northwestern University Medical School, Chicago, IL, USA.
FAU - Clemens, J Q
AU  - Clemens JQ
FAU - Bushman, W
AU  - Bushman W
LA  - eng
GR  - DK02426/DK/NIDDK NIH HHS/United States
GR  - DK52687-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 0 (Homeodomain Proteins)
RN  - 0 (homeobox protein HOXA13)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Homeodomain Proteins/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Mutation
MH  - Prostate/*abnormalities
MH  - Seminal Vesicles/*abnormalities
EDAT- 1999/04/21 00:00
MHDA- 1999/04/21 00:01
CRDT- 1999/04/21 00:00
PHST- 1999/04/21 00:00 [pubmed]
PHST- 1999/04/21 00:01 [medline]
PHST- 1999/04/21 00:00 [entrez]
AID - S0022-5347(05)68999-9 [pii]
PST - ppublish
SO  - J Urol. 1999 May;161(5):1655-61.