PMID- 10209961
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 81
IP  - 3
DP  - 1999 May 5
TI  - Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in
      human tumor cell lines.
PG  - 451-8
AB  - Basic fibroblast growth factor (FGF2) has potent mitogenic and angiogenic
      activities that have been implicated in tumor development and malignant
      progression. The biological effects of FGF2 and other members of the FGF ligand
      family are mediated by 4 transmembrane tyrosine kinase receptors (FGFRs). To
      better understand the roles of FGFRs in cancer, the expression of FGF2 and each
      of the 4 FGFRs was assessed by RNase protection analysis of 60 human tumor cell
      lines, representing 9 tumor types. Expression of at least one FGFR isoform was
      detected in 90% and FGF2 mRNA in 35% of the cell lines. Our comprehensive
      analysis of FGF2 and FGFR expression in human tumor cell lines provides evidence 
      that FGF signaling pathways are active in a majority of human tumor cell lines,
      and lends support to the development of anti-tumor strategies that target FGFRs.
FAU - Chandler, L A
AU  - Chandler LA
AD  - Selective Genetics, Inc., San Diego, CA 92121, USA. loisc@selectivegenetics.com
FAU - Sosnowski, B A
AU  - Sosnowski BA
FAU - Greenlees, L
AU  - Greenlees L
FAU - Aukerman, S L
AU  - Aukerman SL
FAU - Baird, A
AU  - Baird A
FAU - Pierce, G F
AU  - Pierce GF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Fibroblast Growth Factor 2/*analysis/genetics
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - RNA, Messenger/analysis
MH  - Receptors, Fibroblast Growth Factor/*analysis/genetics
MH  - Ribonucleases/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1999/04/21 02:03
MHDA- 2000/06/20 09:00
CRDT- 1999/04/21 02:03
PHST- 1999/04/21 02:03 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/04/21 02:03 [entrez]
AID - 10.1002/(SICI)1097-0215(19990505)81:3<451::AID-IJC20>3.0.CO;2-H [pii]
AID - 10.1002/(sici)1097-0215(19990505)81:3<451::aid-ijc20>3.0.co;2-h [doi]
PST - ppublish
SO  - Int J Cancer. 1999 May 5;81(3):451-8. doi:
      10.1002/(sici)1097-0215(19990505)81:3<451::aid-ijc20>3.0.co;2-h.