PMID- 10209489
OWN - NLM
STAT- MEDLINE
DCOM- 19990426
LR  - 20151119
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 186
IP  - 4
DP  - 1998 Dec
TI  - The MUC6 secretory mucin gene is expressed in a wide variety of epithelial
      tissues.
PG  - 398-405
AB  - Secretory mucins play an important role in the cytoprotection of epithelial
      surfaces and are used as tumour markers in a variety of cancers. The MUC6
      secretory mucin was originally isolated from a gastric cDNA library. The aim was 
      to determine the specific type and location of MUC6 mucin gene expression in a
      wide range of human adult and fetal epithelial tissues. In situ hybridization,
      RNA analysis, and immunohistochemistry were used to quantify and localize mucin
      gene expression. The data obtained show that MUC6 is highly expressed in gastric 
      mucosa, duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic
      centroacinar cells and ducts, and periductal glands of the common bile duct;
      focal expression is seen in basal endometrial and endocervical glands. MUC6
      epitopes were also highly expressed in 7/10 pancreatic cancers and 7/10
      cholangiocarcinomas and focally expressed in 4/10 endocervical adenocarcinomas.
      Expression of MUC6 occurs early in fetal development and was observed in
      Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 
      weeks' gestation. The tissue distribution of the MUC6 secretory mucin indicates
      that it may function to protect epithelial tissues from a wide range of
      substances. Expression of MUC6 is frequently preserved in pancreatic and bile
      duct adenocarcinomas, but it is only sparsely expressed in endocervical
      carcinomas.
FAU - Bartman, A E
AU  - Bartman AE
AD  - Department of Medicine, University of Minnesota, Minneapolis, USA.
FAU - Buisine, M P
AU  - Buisine MP
FAU - Aubert, J P
AU  - Aubert JP
FAU - Niehans, G A
AU  - Niehans GA
FAU - Toribara, N W
AU  - Toribara NW
FAU - Kim, Y S
AU  - Kim YS
FAU - Kelly, E J
AU  - Kelly EJ
FAU - Crabtree, J E
AU  - Crabtree JE
FAU - Ho, S B
AU  - Ho SB
LA  - eng
GR  - CA24321/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MUC6 protein, human)
RN  - 0 (Mucin-6)
RN  - 0 (Mucins)
RN  - 0 (Neoplasm Proteins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Blotting, Northern
MH  - Digestive System/*metabolism
MH  - Digestive System Neoplasms/*metabolism
MH  - Epithelium/metabolism
MH  - Female
MH  - Fetus/metabolism
MH  - Gene Expression
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization
MH  - Male
MH  - Mucin-6
MH  - Mucins/genetics/*metabolism
MH  - Neoplasm Proteins/*metabolism
MH  - RNA/genetics
EDAT- 1999/04/21 02:02
MHDA- 2000/06/20 09:00
CRDT- 1999/04/21 02:02
PHST- 1999/04/21 02:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/04/21 02:02 [entrez]
AID - 10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X [pii]
AID - 10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X [doi]
PST - ppublish
SO  - J Pathol. 1998 Dec;186(4):398-405. doi:
      10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X.