PMID- 10208880
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20071115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 257
IP  - 3
DP  - 1999 Apr 21
TI  - Restricted expression pattern of vegf-d in the adult and fetal mouse: high
      expression in the embryonic lung.
PG  - 891-4
AB  - Endothelial growth factors have become the target of intense research since the
      initial discovery of vascular endothelial growth factor (VEGF/VPF). At present,
      VEGF is established as a major inducer of angiogenesis in normal and pathological
      conditions. Recently several new members in the VEGF family have been described; 
      VEGF-B/VRF, VEGF-C and VEGF-D. VEGF-D is most closely related to VEGF-C by virtue
      of the presence of N- and C-terminal extensions that are not found in other VEGF 
      family members. We have here examined the expression pattern of vegf-d mRNA with 
      in situ hybridization in developing and adult mice. This shows a restricted
      expression pattern, with high levels mainly in lung tissue. The expression in
      embryonic lung is upregulated prior to birth. Expression of vegf-d in other
      tissues, as well as in lung tissue of the E14 embryo, was either low or absent.
      This suggests that VEGF-D may be of special relevance for the vascularization of 
      lung tissue during the last trimester of fetal development.
CI  - Copyright 1999 Academic Press.
FAU - Farnebo, F
AU  - Farnebo F
AD  - CMM L8 02, Karolinska Institute, Stockholm, S-171 76, Sweden.
FAU - Piehl, F
AU  - Piehl F
FAU - Lagercrantz, J
AU  - Lagercrantz J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Oligonucleotides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor D)
SB  - IM
MH  - Animals
MH  - Embryo, Mammalian/metabolism
MH  - Embryonic and Fetal Development
MH  - Endothelial Growth Factors/*genetics
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Kidney/metabolism
MH  - Lung/*embryology/growth & development/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oligonucleotides/genetics
MH  - Organ Specificity
MH  - RNA, Messenger/metabolism
MH  - Seminiferous Tubules/metabolism
MH  - Spine/embryology/metabolism
MH  - Thymus Gland/metabolism
MH  - *Up-Regulation
MH  - Vascular Endothelial Growth Factor D
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - S0006-291X(99)90562-4 [pii]
AID - 10.1006/bbrc.1999.0562 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Apr 21;257(3):891-4. doi:
      10.1006/bbrc.1999.0562.