PMID- 10208738
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20071114
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 209
IP  - 1
DP  - 1999 May 1
TI  - Developmental competence of the gut endoderm: genetic potentiation by GATA and
      HNF3/fork head proteins.
PG  - 1-10
AB  - A long-standing problem in developmental biology has been to understand how the
      embryonic germ layers gain the competence to differentiate into distinct cell
      types. Genetic studies have shown that members of the GATA and HNF3/fork head
      transcription factor families are essential for the formation and differentiation
      of gut endoderm tissues in worms, flies, and mammals. Recent in vivo footprinting
      studies have shown that GATA and HNF3 binding sites in chromatin are occupied on 
      a silent gene in endoderm that has the potential to be activated solely in that
      germ layer. These and other data indicate that these evolutionarily conserved
      factors help impart the competence of a gene to be activated in development, a
      phenomenon called genetic potentiation. The mechanistic implications of genetic
      potentiation and its general significance are discussed.
CI  - Copyright 1999 Academic Press.
FAU - Zaret, K
AU  - Zaret K
AD  - Department of Molecular Biology, Cell Biology, and Biochemistry, Brown
      University, Providence, Rhode Island 02912, USA.
LA  - eng
GR  - GM36477/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (FOXI1 protein, human)
RN  - 0 (FOXJ1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - DNA Footprinting/methods
MH  - *DNA-Binding Proteins
MH  - Endoderm/*metabolism
MH  - Evolution, Molecular
MH  - Forkhead Transcription Factors
MH  - *Gene Expression Regulation, Developmental
MH  - Intestines/*embryology
MH  - Mice
MH  - Models, Biological
MH  - Morphogenesis
MH  - Trans-Activators/*genetics
MH  - *Transcription Factors
RF  - 114
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - S0012-1606(99)99228-X [pii]
AID - 10.1006/dbio.1999.9228 [doi]
PST - ppublish
SO  - Dev Biol. 1999 May 1;209(1):1-10. doi: 10.1006/dbio.1999.9228.