PMID- 10208429
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20091119
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 9
DP  - 1999 Mar 4
TI  - The translation initiation factor, hu-Sui1 may be a target of hepatitis B X
      antigen in hepatocarcinogenesis.
PG  - 1677-87
AB  - The role of hepatitis B virus X antigen in the development of hepatocellular
      carcinoma was explored by stably transfecting HepG2 cells with an X antigen
      expression vector, and identifying the differences in gene expression that
      distinguish X positive from X negative cells by subtractive PCR. One
      differentially expressed gene, the human homolog of sui1 (hu-sui1), encodes a
      translation initiation factor whose expression was suppressed by X antigen in
      HepG2 cells. Hu-Sui1 was also expressed in nontumor liver but not in tumor cells 
      from patients with hepatocellular carcinoma. Introduction of hu-sui1 into HepG2
      cells inhibited cell growth in culture, in soft agar, and partially inhibited
      tumor formation in nude mice. Hence, the suppression of hu-sui1 by X antigen may 
      result in the abrogation of negative growth regulation and contribute to the
      development of hepatocellular carcinoma.
FAU - Lian, Z
AU  - Lian Z
AD  - Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University,
      Philadelphia, Pennsylvania 19107-6799, USA.
FAU - Pan, J
AU  - Pan J
FAU - Liu, J
AU  - Liu J
FAU - Zhang, S
AU  - Zhang S
FAU - Zhu, M
AU  - Zhu M
FAU - Arbuthnot, P
AU  - Arbuthnot P
FAU - Kew, M
AU  - Kew M
FAU - Feitelson, M A
AU  - Feitelson MA
LA  - eng
SI  - GENBANK/L26247
GR  - CA48656/CA/NCI NIH HHS/United States
GR  - CA66971/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA, Complementary)
RN  - 0 (Eukaryotic Initiation Factor-1)
RN  - 0 (Fungal Proteins)
RN  - 0 (Peptide Initiation Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (SUI1 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (hepatitis B virus X protein)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Carcinoma, Hepatocellular/physiopathology
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Eukaryotic Initiation Factor-1
MH  - Fungal Proteins/genetics/*metabolism
MH  - Hepatitis B
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - Molecular Sequence Data
MH  - Peptide Initiation Factors/genetics/*metabolism
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
AID - 10.1038/sj.onc.1202470 [doi]
PST - ppublish
SO  - Oncogene. 1999 Mar 4;18(9):1677-87. doi: 10.1038/sj.onc.1202470.