PMID- 10207622
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20091119
IS  - 0067-8694 (Print)
IS  - 0067-8694 (Linking)
VI  - 64
DP  - 1999
TI  - Regulation of actin dynamics by stress-activated protein kinase 2
      (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27).
PG  - 79-89
AB  - Activation of the mitogen-activated protein kinase (MAP kinase) SAPK2
      (stress-activated protein kinase 2) leads to the phosphorylation of several
      transcription factors and cytoplasmic proteins, and thereby presumably
      orchestrates important specific cellular responses to numerous cytokines,
      stressing agents and agonists of tyrosine kinase or serpentine receptors. The
      heat-shock protein of 27 kDa (Hsp27), a downstream target of the SAPK2-activated 
      MAP-kinase-activated protein kinase-2/3, has a documented function as an actin
      polymerization modulator. Accordingly, recent evidence implicates the SAPK2
      pathway in the modulation of microfilament dynamics in response to stress and
      agonist stimulation. In vascular endothelial cells, where the basal level of
      expression of Hsp27 is high, SAPK2 mediates oxidative stress- and vascular
      endothelial growth factor (VEGF)-induced actin reorganization and VEGF-induced
      cell migration, suggesting a key role for this MAP kinase pathway in inflammation
      and angiogenic processes.
FAU - Landry, J
AU  - Landry J
AD  - Centre de recherche en cancerologie de l'Universite Laval, Centre Hospitalier
      Universitaire de Quebec, Canada.
FAU - Huot, J
AU  - Huot J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Symp
JT  - Biochemical Society symposium
JID - 7506896
RN  - 0 (Actins)
RN  - 0 (Growth Substances)
RN  - 0 (Heat-Shock Proteins)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Actins/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Growth Substances/physiology
MH  - Heat-Shock Proteins/*metabolism
MH  - Humans
MH  - *Mitogen-Activated Protein Kinases
MH  - Oxidative Stress
MH  - Phosphorylation
MH  - p38 Mitogen-Activated Protein Kinases
RF  - 40
EDAT- 1999/04/20 00:00
MHDA- 1999/04/20 00:01
CRDT- 1999/04/20 00:00
PHST- 1999/04/20 00:00 [pubmed]
PHST- 1999/04/20 00:01 [medline]
PHST- 1999/04/20 00:00 [entrez]
PST - ppublish
SO  - Biochem Soc Symp. 1999;64:79-89.