PMID- 10207104
OWN - NLM
STAT- MEDLINE
DCOM- 19990518
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 5
DP  - 1999 May
TI  - HERF1, a novel hematopoiesis-specific RING finger protein, is required for
      terminal differentiation of erythroid cells.
PG  - 3808-15
AB  - The AML1/core binding factor beta (CBFbeta) transcription factor is essential for
      definitive hematopoiesis; however, the downstream pathways through which it
      functions remain incompletely defined. Using a differential cloning approach to
      define components of this pathway, we have identified a novel gene designated
      HERF1 (for hematopoietic RING finger 1), whose expression during development is
      dependent on the presence of functional AML1/CBFbeta. HERF1 contains a tripartite
      RING finger-B box-alpha-helical coiled-coil domain and a C-terminal region
      homologous to the ret proto-oncogene-encoded finger protein. Expression of HERF1 
      during embryogenesis coincides with the appearance of definitive erythropoiesis
      and in adult mice is restricted to erythroid cells, increasing 30-fold during
      terminal differentiation. Importantly, inhibition of HERF1 expression blocked
      terminal erythroid differentiation of the murine erythroleukemia cell line MEL,
      whereas its overexpression induced erythroid maturation. These results suggest an
      important role for this protein in erythropoiesis.
FAU - Harada, H
AU  - Harada H
AD  - Departments of Pathology and Laboratory Medicine, St. Jude Children's Research
      Hospital, Memphis, Tennessee, USA.
FAU - Harada, Y
AU  - Harada Y
FAU - O'Brien, D P
AU  - O'Brien DP
FAU - Rice, D S
AU  - Rice DS
FAU - Naeve, C W
AU  - Naeve CW
FAU - Downing, J R
AU  - Downing JR
LA  - eng
SI  - GENBANK/AF134811
GR  - P01 CA071907/CA/NCI NIH HHS/United States
GR  - P30 CA021765/CA/NCI NIH HHS/United States
GR  - CA-21765/CA/NCI NIH HHS/United States
GR  - P01 CA71907-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Carrier Proteins)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Runx1 protein, mouse)
RN  - 0 (TRIM10 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - F8VB5M810T (Tetracycline)
RN  - YOW8V9698H (Dimethyl Sulfoxide)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*genetics
MH  - Cell Differentiation/*genetics
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA-Binding Proteins
MH  - Dimethyl Sulfoxide
MH  - Erythropoiesis/*genetics
MH  - Gene Expression Regulation, Developmental/genetics
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Structure, Secondary
MH  - *Proto-Oncogene Proteins
MH  - RNA, Messenger/genetics
MH  - Tetracycline/pharmacology
MH  - Transcription Factors/genetics
MH  - Zinc Fingers/*genetics
PMC - PMC84222
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1128/mcb.19.5.3808 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 May;19(5):3808-15. doi: 10.1128/mcb.19.5.3808.