PMID- 10207097
OWN - NLM
STAT- MEDLINE
DCOM- 19990518
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 5
DP  - 1999 May
TI  - Activation of somatostatin receptor II expression by transcription factors MIBP1 
      and SEF-2 in the murine brain.
PG  - 3736-47
AB  - Somatostatin receptor type II expression in the mammalian brain displays a
      spatially and temporally very restricted pattern. In an investigation of the
      molecular mechanisms controlling these patterns, we have recently shown that
      binding of the transcription factor SEF-2 to a novel initiator element in the
      SSTR-2 promoter is essential for SSTR-2 gene expression. Further characterization
      of the promoter identified a species-conserved TC-rich enhancer element. By
      screening a mouse brain cDNA expression library, we cloned a cDNA encoding the
      transcription factor MIBP1. MIBP1 interacts specifically with both the TC box in 
      the SSTR-2 promoter and with the SEF-2 initiator-binding protein to enhance
      transcription from the basal SSTR-2 promoter. We then investigated SSTR-2, SEF-2,
      and MIBP1 mRNA expression patterns in the developing and adult murine brain by
      Northern blotting and in situ hybridization. While SEF-2 is widely expressed in
      many neuronal and nonneuronal tissues, MIBP1 expression overlapped precisely with
      expression of SSTR-2 in the frontal cortex and hippocampus. In summary, our data 
      for the first time define a regulatory role for the transcription factor MIBP1 in
      mediating spatially and temporally regulated SSTR-2 expression in the brain.
FAU - Dorflinger, U
AU  - Dorflinger U
AD  - Institut fur Experimentelle Krebsforschung, Klinik fur Tumorbiologie an der
      Universitat Freiburg, D-79106 Freiburg, Klinikum der RWTH Aachen, D-52074 Aachen,
      Germany.
FAU - Pscherer, A
AU  - Pscherer A
FAU - Moser, M
AU  - Moser M
FAU - Rummele, P
AU  - Rummele P
FAU - Schule, R
AU  - Schule R
FAU - Buettner, R
AU  - Buettner R
LA  - eng
SI  - GENBANK/Y15907
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hivep2 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Somatostatin)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TCF Transcription Factors)
RN  - 0 (Tcf4 protein, mouse)
RN  - 0 (Tcf4 protein, rat)
RN  - 0 (Transcription Factor 4)
RN  - 0 (Transcription Factors)
RN  - 148770-78-9 (HIVEP2 protein, human)
RN  - D73QL0OMU2 (somatostatin receptor 2)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - Brain/embryology/*metabolism
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Embryonic and Fetal Development
MH  - Gene Expression Regulation, Developmental/genetics
MH  - Gene Library
MH  - Genes, Reporter/genetics
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Promoter Regions, Genetic/genetics
MH  - RNA, Messenger/metabolism
MH  - Receptors, Somatostatin/*genetics
MH  - Recombinant Proteins/metabolism
MH  - Sequence Homology, Amino Acid
MH  - TCF Transcription Factors
MH  - Transcription Factor 4
MH  - Transcription Factors/*genetics/metabolism
MH  - Transcriptional Activation/*genetics
PMC - PMC84194
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1128/mcb.19.5.3736 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 May;19(5):3736-47. doi: 10.1128/mcb.19.5.3736.