PMID- 10206894
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 283
IP  - 5409
DP  - 1999 Mar 19
TI  - Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.
PG  - 1914-9
AB  - Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and
      other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the 
      extensive fat losses associated with some advanced cancers. The 2.8 angstrom
      crystal structure of ZAG resembles a class I major histocompatibility complex
      (MHC) heavy chain, but ZAG does not bind the class I light chain
      beta2-microglobulin. The ZAG structure includes a large groove analogous to class
      I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a
      nonpeptidic compound that may be implicated in lipid catabolism under normal or
      pathological conditions.
FAU - Sanchez, L M
AU  - Sanchez LM
AD  - Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
FAU - Chirino, A J
AU  - Chirino AJ
FAU - Bjorkman, P j
AU  - Bjorkman Pj
LA  - eng
SI  - PDB/1ZAG
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Glycoproteins)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Peptides)
RN  - 0 (Seminal Plasma Proteins)
RN  - 0 (Zn-alpha-2-glycoprotein)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Binding Sites
MH  - Crystallography, X-Ray
MH  - Glycoproteins/blood/*chemistry/isolation & purification/metabolism
MH  - Glycosylation
MH  - HLA-A2 Antigen/chemistry/metabolism
MH  - Histocompatibility Antigens Class I/*chemistry
MH  - Humans
MH  - Hydrogen Bonding
MH  - Ligands
MH  - Lipid Metabolism
MH  - Models, Molecular
MH  - Peptides/metabolism
MH  - Protein Binding
MH  - Protein Conformation
MH  - Protein Folding
MH  - Protein Structure, Secondary
MH  - Protein Structure, Tertiary
MH  - *Seminal Plasma Proteins
MH  - beta 2-Microglobulin/metabolism
EDAT- 1999/04/17 00:00
MHDA- 1999/04/17 00:01
CRDT- 1999/04/17 00:00
PHST- 1999/04/17 00:00 [pubmed]
PHST- 1999/04/17 00:01 [medline]
PHST- 1999/04/17 00:00 [entrez]
AID - 10.1126/science.283.5409.1914 [doi]
PST - ppublish
SO  - Science. 1999 Mar 19;283(5409):1914-9. doi: 10.1126/science.283.5409.1914.