PMID- 10204488
OWN - NLM
STAT- MEDLINE
DCOM- 19990423
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Mar
TI  - Essential role of LAT in T cell development.
PG  - 323-32
AB  - The linker molecule LAT is a substrate of the tyrosine kinases activated
      following TCR engagement. Phosphorylated LAT binds many critical signaling
      molecules. The central role of this molecule in TCR-mediated signaling has been
      demonstrated by experiments in a LAT-deficient cell line. To probe the role of
      LAT in T cell development, the LAT gene was disrupted by targeting. LAT-deficient
      mice appeared healthy. Flow cytometric analysis revealed normal B cell
      populations but the absence of any mature peripheral T cells. Intrathymic
      development was blocked within the CD4- CD8- stage. No gross abnormality of NK or
      platelet function was observed. LAT is thus critical to both T cell activation
      and development.
FAU - Zhang, W
AU  - Zhang W
AD  - Section on Lymphocyte Signaling, Cell Biology and Metabolism Branch, National
      Institute of Child Health and Human Development, National Institutes of Health,
      Bethesda, Maryland 20892, USA.
FAU - Sommers, C L
AU  - Sommers CL
FAU - Burshtyn, D N
AU  - Burshtyn DN
FAU - Stebbins, C C
AU  - Stebbins CC
FAU - DeJarnette, J B
AU  - DeJarnette JB
FAU - Trible, R P
AU  - Trible RP
FAU - Grinberg, A
AU  - Grinberg A
FAU - Tsay, H C
AU  - Tsay HC
FAU - Jacobs, H M
AU  - Jacobs HM
FAU - Kessler, C M
AU  - Kessler CM
FAU - Long, E O
AU  - Long EO
FAU - Love, P E
AU  - Love PE
FAU - Samelson, L E
AU  - Samelson LE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Lat protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Carrier Proteins/genetics/immunology/*physiology
MH  - Cell Differentiation/immunology
MH  - Killer Cells, Natural/cytology/immunology
MH  - Membrane Proteins/genetics/immunology/*physiology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Phosphoproteins/genetics/immunology/*physiology
MH  - Receptors, Antigen, T-Cell/genetics/physiology
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics/metabolism
MH  - Signal Transduction/genetics/immunology
MH  - T-Lymphocyte Subsets/cytology/*immunology
EDAT- 1999/04/16 00:00
MHDA- 1999/04/16 00:01
CRDT- 1999/04/16 00:00
PHST- 1999/04/16 00:00 [pubmed]
PHST- 1999/04/16 00:01 [medline]
PHST- 1999/04/16 00:00 [entrez]
AID - S1074-7613(00)80032-1 [pii]
AID - 10.1016/s1074-7613(00)80032-1 [doi]
PST - ppublish
SO  - Immunity. 1999 Mar;10(3):323-32. doi: 10.1016/s1074-7613(00)80032-1.