PMID- 10204086
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20191024
IS  - 1039-9712 (Print)
IS  - 1039-9712 (Linking)
VI  - 47
IP  - 3
DP  - 1999 Mar
TI  - Cloning and characterization of the non-catalytic heavy chain of mouse complement
      factor I gene: structure comparison with the human homologue.
PG  - 493-500
AB  - The gene sequence encoding the non-catalytic heavy chain of mouse complement
      factor I (mCFI) was cloned and its exon-intron organization and domain structure 
      characterized. The genomic organization of mCFI differs in several aspects from
      its human homologue (hCFI). The intron sizes are remarkably different. Exons 2
      and 4 in mCFI are larger than their counterparts in hCFI by 9 bp and 6 bp
      respectively. Whereas the diversity (D) region of hCFI is encoded by two exons
      (exon 7 or hD2 and exon 8 or hD4), this region in mCFI is encoded by three exons;
      exon 6A or mD1 (located at the 3'-end of the LDLr A2 domain), exon 7 or mD2 and
      exon 8, an extended exon (56 bp) composed of mD3, fused upstream of mD4. In
      contrast, hCFI lacks D1 and D3 subregions and exon 8 in hCFI consists of only
      hD4, 36 bp in length. Thus the heavy chain of mCFI is organized into 10 exons
      compared to 9 exons in hCFI.
FAU - Yun, Y S
AU  - Yun YS
AD  - Department of Laboratory Medicine and Pathobiology, University of Toronto,
      Canada.
FAU - Goldberger, G
AU  - Goldberger G
FAU - Minta, J O
AU  - Minta JO
LA  - eng
SI  - GENBANK/AF100559
SI  - GENBANK/AF100560
SI  - GENBANK/AF100561
SI  - GENBANK/AF100562
SI  - GENBANK/AF100563
SI  - GENBANK/AF100564
SI  - GENBANK/AF100565
SI  - GENBANK/AH007741
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem Mol Biol Int
JT  - Biochemistry and molecular biology international
JID - 9306673
RN  - EC 3.4.21.45 (Complement Factor I)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Complement Factor I/chemistry/*genetics
MH  - Dimerization
MH  - Exons/genetics
MH  - Female
MH  - Humans
MH  - Introns/genetics
MH  - Mice
MH  - Molecular Sequence Data
EDAT- 1999/04/16 00:00
MHDA- 1999/04/16 00:01
CRDT- 1999/04/16 00:00
PHST- 1999/04/16 00:00 [pubmed]
PHST- 1999/04/16 00:01 [medline]
PHST- 1999/04/16 00:00 [entrez]
AID - 10.1080/15216549900201523 [doi]
PST - ppublish
SO  - Biochem Mol Biol Int. 1999 Mar;47(3):493-500. doi: 10.1080/15216549900201523.