PMID- 10204077
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20191024
IS  - 1039-9712 (Print)
IS  - 1039-9712 (Linking)
VI  - 47
IP  - 3
DP  - 1999 Mar
TI  - Isolation and characterization of cDNA clone for human liver
      10-formyltetrahydrofolate dehydrogenase.
PG  - 407-15
AB  - A cDNA clone encoding 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) was
      isolated from a human fetal liver cDNA library. It contained the open reading
      frame of 2,709 base pairs and predicted a protein comprising 902 amino acids with
      a calculated molecular weight of 98,700 Da. The deduced protein showed about
      93.6% homology (90.5% identity, 3.1% favored substitutions) when compared with
      rat 10-FTHFDH. The distribution of 10-FTHFDH transcript in various human tissues 
      was studied by Northern blot analysis using poly(A+) RNAs from different tissues.
      The 10-FTHFDH transcript with an approximate size of 2.7 kb was mainly expressed 
      in human kidney, skeletal muscle, and liver and rarely expressed in other
      tissues.
FAU - Hong, M
AU  - Hong M
AD  - Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
FAU - Lee, Y
AU  - Lee Y
FAU - Kim, J W
AU  - Kim JW
FAU - Lim, J S
AU  - Lim JS
FAU - Chang, S Y
AU  - Chang SY
FAU - Lee, K S
AU  - Lee KS
FAU - Paik, S G
AU  - Paik SG
FAU - Choe, I S
AU  - Choe IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biochem Mol Biol Int
JT  - Biochemistry and molecular biology international
JID - 9306673
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors)
RN  - EC 1.5.1.6 (formyltetrahydrofolate dehydrogenase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - Liver/embryology/*enzymology
MH  - Molecular Sequence Data
MH  - Oxidoreductases Acting on CH-NH Group Donors/chemistry/*genetics
MH  - RNA, Messenger/metabolism
MH  - Restriction Mapping
MH  - Sequence Homology, Amino Acid
EDAT- 1999/04/16 00:00
MHDA- 1999/04/16 00:01
CRDT- 1999/04/16 00:00
PHST- 1999/04/16 00:00 [pubmed]
PHST- 1999/04/16 00:01 [medline]
PHST- 1999/04/16 00:00 [entrez]
AID - 10.1080/15216549900201433 [doi]
PST - ppublish
SO  - Biochem Mol Biol Int. 1999 Mar;47(3):407-15. doi: 10.1080/15216549900201433.