PMID- 10203854
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20191210
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 22
IP  - 4
DP  - 1999 Apr
TI  - The EGR family of transcription-regulatory factors: progress at the interface of 
      molecular and systems neuroscience.
PG  - 167-73
AB  - The EGR family of transcription regulatory factors, which is implicated in
      orchestrating the changes in gene expression that underlie neuronal plasticity,
      has attracted the attention of both molecular and systems neuroscientists. In
      this article, the advances made in both these fields of research are reviewed.
      Recent systems-based studies underscore the remarkable sensitivity and
      specificity of the induction of the expression of genes encoding EGR-family
      members in naturally occurring plasticity paradigms. However, they also challenge
      conventional views of the role of this family in plasticity. Recent molecular
      studies have identified the gonadotropin subunit, luteinizing hormone beta, as an
      EGR1-regulated gene in vivo and uncovered an essential role for EGR3 in
      muscle-spindle development. In addition, the discovery of novel proteins that are
      capable of suppressing EGR-mediated transcription cast doubt over the prevalent
      assumption that changes in EGR mRNA or protein levels provide an accurate measure
      of EGR-driven transcriptional activity.
FAU - O'Donovan, K J
AU  - O'Donovan KJ
AD  - Dept of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 
      21205, USA.
FAU - Tourtellotte, W G
AU  - Tourtellotte WG
FAU - Millbrandt, J
AU  - Millbrandt J
FAU - Baraban, J M
AU  - Baraban JM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (Early Growth Response Transcription Factors)
RN  - 0 (Egr1 protein, mouse)
RN  - 0 (Egr2 protein, mouse)
RN  - 0 (Egr3 protein, mouse)
RN  - 0 (Egr4 protein, mouse)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
RN  - 144516-98-3 (Early Growth Response Protein 3)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Circadian Rhythm/physiology
MH  - DNA-Binding Proteins/genetics/metabolism/*physiology
MH  - Discrimination, Psychological/physiology
MH  - Dopamine/physiology
MH  - Early Growth Response Protein 1
MH  - Early Growth Response Protein 2
MH  - Early Growth Response Protein 3
MH  - Early Growth Response Transcription Factors
MH  - Female
MH  - Gene Expression Regulation/*physiology
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Genes, Immediate-Early
MH  - *Immediate-Early Proteins
MH  - Infertility/genetics
MH  - Learning/physiology
MH  - Luteinizing Hormone/genetics/physiology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Multigene Family
MH  - Muscle Spindles/abnormalities/physiology
MH  - Nerve Tissue Proteins/deficiency/genetics/*physiology
MH  - Nervous System Malformations/genetics
MH  - Neuronal Plasticity/physiology
MH  - Norepinephrine/physiology
MH  - Songbirds/physiology
MH  - Synaptic Transmission/physiology
MH  - Transcription Factors/genetics/metabolism/*physiology
MH  - Transcription, Genetic
MH  - Visual Perception/physiology
MH  - Vocalization, Animal/physiology
RF  - 52
EDAT- 1999/04/24 00:00
MHDA- 1999/04/24 00:01
CRDT- 1999/04/24 00:00
PHST- 1999/04/24 00:00 [pubmed]
PHST- 1999/04/24 00:01 [medline]
PHST- 1999/04/24 00:00 [entrez]
AID - S0166-2236(98)01343-5 [pii]
AID - 10.1016/s0166-2236(98)01343-5 [doi]
PST - ppublish
SO  - Trends Neurosci. 1999 Apr;22(4):167-73. doi: 10.1016/s0166-2236(98)01343-5.