PMID- 10202016
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 8
DP  - 1999 Apr 15
TI  - A new member of the Ig superfamily and a V-ATPase G subunit are among the
      predicted products of novel genes close to the TNF locus in the human MHC.
PG  - 4745-54
AB  - It is becoming increasingly apparent that many of the genes in the class III
      region of the human MHC encode proteins involved in the immune and inflammatory
      responses. Furthermore, genetic studies have indicated that genes within the
      class III region, particularly the telomeric segment containing the TNF gene,
      could contribute to susceptibility to diseases of immune-related etiology. We
      have sequenced an 82-kb segment of DNA around the TNF gene to identify candidate 
      disease susceptibility genes in this region. The 10 known genes in this region
      have been precisely positioned with the order allograft inflammatory factor 1,
      G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin 
      A, NB6, IKBL, BAT1 (centromere to telomere), and their genomic structures have
      been defined. Comparison of the G1 genomic region with previously described cDNA 
      and genomic sequences, together with the results of reverse transcriptase-PCR,
      indicates that three alternative transcripts, G1, allograft inflammatory factor
      1, and IFN-gamma-responsive transcript, are all derived from this gene. The
      completion of the sequence of 1C7 (D6S2570) has revealed that this gene encodes a
      putative novel member of the Ig superfamily. A number of alternatively spliced
      transcripts of 1C7 were identified by reverse transcriptase-PCR, all of which are
      expressed in immune-related cell lines. Alternative splicing within the Ig
      domain-encoding region was seen to result in possible set switching between an
      IgV domain and an IgC2 domain. Lastly, a previously unidentified gene, homologous
      to a number of V-ATPase G subunits, has been located 1 kb telomeric of IKBL.
FAU - Neville, M J
AU  - Neville MJ
AD  - Medical Research Council Immunochemistry Unit, Department of Biochemistry,
      University of Oxford, United Kingdom.
FAU - Campbell, R D
AU  - Campbell RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Blood Proteins)
RN  - 0 (LST1 protein, human)
RN  - 0 (Lst1 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.6.1.- (Vacuolar Proton-Translocating ATPases)
RN  - EC 3.6.3.14 (Proton-Translocating ATPases)
SB  - AIM
SB  - IM
MH  - Alternative Splicing/immunology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blood Proteins/genetics
MH  - Carps
MH  - Exons
MH  - *Genes, Immunoglobulin
MH  - Humans
MH  - Introns
MH  - Major Histocompatibility Complex/*genetics
MH  - Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Open Reading Frames/immunology
MH  - Proton-Translocating ATPases/*genetics
MH  - Rats
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Swine
MH  - Tumor Cells, Cultured
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - *Vacuolar Proton-Translocating ATPases
MH  - Zebrafish
EDAT- 1999/04/14 00:00
MHDA- 1999/04/14 00:01
CRDT- 1999/04/14 00:00
PHST- 1999/04/14 00:00 [pubmed]
PHST- 1999/04/14 00:01 [medline]
PHST- 1999/04/14 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 Apr 15;162(8):4745-54.