PMID- 10201375
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20161230
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 398
IP  - 6726
DP  - 1999 Apr 1
TI  - A capsaicin-receptor homologue with a high threshold for noxious heat.
PG  - 436-41
AB  - Pain-producing heat is detected by several classes of nociceptive sensory neuron 
      that differ in their thermal response thresholds. The cloned capsaicin receptor, 
      also known as the vanilloid receptor subtype 1 (VR1), is a heat-gated ion channel
      that has been proposed to mediate responses of small-diameter sensory neurons to 
      moderate (43 degrees C) thermal stimuli. VR1 is also activated by protons,
      indicating that it may participate in the detection of noxious thermal and
      chemical stimuli in vivo. Here we identify a structurally related receptor,
      VRL-1, that does not respond to capsaicin, acid or moderate heat. Instead, VRL-1 
      is activated by high temperatures, with a threshold of approximately 52 degrees
      C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of
      medium- to large-diameter neurons, making it a candidate receptor for transducing
      high-threshold heat responses in this class of cells. VRL-1 transcripts are not
      restricted to the sensory nervous system, indicating that this channel may be
      activated by stimuli other than heat. We propose that responses to noxious heat
      involve these related, but distinct, ion-channel subtypes that together detect a 
      range of stimulus intensities.
FAU - Caterina, M J
AU  - Caterina MJ
AD  - Department of Cellular and Molecular Pharmacology, University of California, San 
      Francisco 94143-0450, USA.
FAU - Rosen, T A
AU  - Rosen TA
FAU - Tominaga, M
AU  - Tominaga M
FAU - Brake, A J
AU  - Brake AJ
FAU - Julius, D
AU  - Julius D
LA  - eng
SI  - GENBANK/AF129112
SI  - GENBANK/AF129113
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Receptors, Drug)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 receptor)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Capsaicin/*metabolism
MH  - Cell Line
MH  - Ganglia, Sensory/metabolism
MH  - *Hot Temperature
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neurons/metabolism
MH  - Nociceptors/*metabolism
MH  - Rats
MH  - Receptors, Drug/chemistry/*metabolism
MH  - Sensory Thresholds
MH  - Sequence Homology, Amino Acid
MH  - TRPV Cation Channels
MH  - Xenopus
EDAT- 1999/04/14 02:03
MHDA- 2001/03/23 10:01
CRDT- 1999/04/14 02:03
PHST- 1999/04/14 02:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/04/14 02:03 [entrez]
AID - 10.1038/18906 [doi]
PST - ppublish
SO  - Nature. 1999 Apr 1;398(6726):436-41. doi: 10.1038/18906.