PMID- 10200909
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20071115
IS  - 1045-4403 (Print)
IS  - 1045-4403 (Linking)
VI  - 9
IP  - 1
DP  - 1999
TI  - CREB-mediated transcriptional control.
PG  - 19-32
AB  - cAMP-response-element-binding protein, CREB, is a 43-kDa leucine zipper
      transcription factor identified and cloned via the study of cAMP-regulated genes.
      In the last decade, numerous studies have contributed much to our understanding
      of CREB structure, function, and CREB-mediated transcription. CREB binds to the
      cAMP-response-element (CRE) as a homodimer formed via the leucine zipper motif
      present at its C-terminus; its transcriptional activity is regulated by
      phosphorylation at Ser133, located within the N-terminal transactivation domain. 
      Active, Ser133-phosphorylated CREB effects transcription of CRE-dependent genes
      via interaction with the 265-kDa co-activator protein CREB-binding-protein, CBP, 
      which bridges the CRE/CREB complex to components of the basal transcriptional
      apparatus. This mechanism of CREB activation is effected by diverse signals,
      including those regulating the intracellular levels of cAMP and Ca+2, growth
      factors, and cellular stress. Accordingly, CREB-mediated transcription regulates 
      diverse cellular responses, including intermediary metabolism, neuronal
      signaling, cell proliferation, and apoptosis. In addition to the regulation of
      CREB by phosphorylation, the viral oncoproteins HBV pX and HTLVI Tax regulate
      CREB transcriptional efficacy by an alternative mechanism, by increasing its
      DNA-binding affinity for viral and/or cellular CRE sites. In this review I
      describe key experiments that have defined the mechanism of CREB activation, with
      primary emphasis on emerging evidence linking CREB to cellular growth and
      development.
FAU - Andrisani, O M
AU  - Andrisani OM
AD  - Department of Basic Medical Sciences, Purdue University, West Lafayette, IN
      47907-1246, USA.
LA  - eng
GR  - DK44533/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Crit Rev Eukaryot Gene Expr
JT  - Critical reviews in eukaryotic gene expression
JID - 9007261
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Cell Nucleus/metabolism
MH  - Cloning, Molecular
MH  - Cyclic AMP Response Element-Binding Protein/*genetics/metabolism
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Signal Transduction/genetics
MH  - Transcription, Genetic/*genetics
RF  - 132
EDAT- 1999/04/14 00:00
MHDA- 1999/04/14 00:01
CRDT- 1999/04/14 00:00
PHST- 1999/04/14 00:00 [pubmed]
PHST- 1999/04/14 00:01 [medline]
PHST- 1999/04/14 00:00 [entrez]
PST - ppublish
SO  - Crit Rev Eukaryot Gene Expr. 1999;9(1):19-32.