PMID- 10200259
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 8
DP  - 1999 Apr 13
TI  - A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle
      assembly checkpoint protein MAD2.
PG  - 4313-8
AB  - Recently a number of nonclass I genes were discovered in the human MHC class I
      region. One of these, FAT10, encodes a protein consisting of two domains with
      homology to ubiquitin. FAT10 mRNA is expressed constitutively in some
      lymphoblastoid lines and dendritic cells and in certain other cells after
      gamma-interferon induction. FAT10 protein expression is controlled at several
      levels including transcription, translation, and protein stability. Yeast
      two-hybrid screening of a human lymphocyte library and immunoprecipitation
      studies revealed that FAT10 noncovalently associated with MAD2, a protein
      implicated in a cell-cycle checkpoint for spindle assembly during anaphase. Thus,
      FAT10 may modulate cell growth during B cell or dendritic cell development and
      activation.
FAU - Liu, Y C
AU  - Liu YC
AD  - Department of Genetics, Internal Medicine, Boyer Center for Molecular Medicine,
      Yale University School of Medicine, New Haven, CT 06511, USA.
FAU - Pan, J
AU  - Pan J
FAU - Zhang, C
AU  - Zhang C
FAU - Fan, W
AU  - Fan W
FAU - Collinge, M
AU  - Collinge M
FAU - Bender, J R
AU  - Bender JR
FAU - Weissman, S M
AU  - Weissman SM
LA  - eng
SI  - GENBANK/AF123050
GR  - R01 HL043331/HL/NHLBI NIH HHS/United States
GR  - CA42556-10/CA/NCI NIH HHS/United States
GR  - HL43331/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (MAD2L1 protein, human)
RN  - 0 (Mad2 Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (UBD protein, human)
RN  - 0 (Ubiquitins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Base Sequence
MH  - COS Cells
MH  - *Calcium-Binding Proteins
MH  - Carrier Proteins/chemistry/*genetics/*metabolism
MH  - Cell Cycle Proteins
MH  - Cell Line
MH  - Chromosomes, Artificial, Yeast
MH  - Genes, MHC Class I
MH  - HL-60 Cells
MH  - Humans
MH  - Jurkat Cells
MH  - Mad2 Proteins
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Repressor Proteins
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/immunology
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Ubiquitins/chemistry
PMC - PMC16329
EDAT- 1999/04/14 00:00
MHDA- 1999/04/14 00:01
CRDT- 1999/04/14 00:00
PHST- 1999/04/14 00:00 [pubmed]
PHST- 1999/04/14 00:01 [medline]
PHST- 1999/04/14 00:00 [entrez]
AID - 10.1073/pnas.96.8.4313 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4313-8. doi: 10.1073/pnas.96.8.4313.