PMID- 10199968
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20191210
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 296
IP  - 1
DP  - 1999 Apr
TI  - Formin defines a large family of morphoregulatory genes and functions in
      establishment of the polarising region.
PG  - 85-93
AB  - Formin was originally isolated as the gene affected by the murine limb deformity 
      (ld) mutations, which disrupt the epithelial-mesenchymal interactions regulating 
      patterning of the vertebrate limb autopod. More recently, a rapidly growing
      number of genes with similarity to formin have been isolated from many different 
      species including fungi and plants. Genetic and biochemical analysis shows that
      formin family members function in cellular processes regulating either
      cytokinesis and/or cell polarisation. Another common feature among formin family 
      members is their requirement in morphogenetic processes such as budding and
      conjugation of yeast, establishment of Drosophila oocyte polarity and vertebrate 
      limb pattern formation. Vertebrate formins are predominantly nuclear proteins
      which control polarising activity in limb buds through establishment of the
      SHH/FGF-4 feedback loop. Formin acts in the limb bud mesenchyme to induce apical 
      ectodermal ridge (AER) differentiation and FGF-4 expression in the posterior AER 
      compartment. Finally, disruption of the epithelial-mesenchymal interactions
      controlling induction of metanephric kidneys in ld mutant embryos indicates that 
      formin might function more generally in transduction of morphogenetic signals
      during embryonic pattern formation.
FAU - Zeller, R
AU  - Zeller R
AD  - European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg,
      Germany. r.zeller@bio.uu.nl
FAU - Haramis, A G
AU  - Haramis AG
FAU - Zuniga, A
AU  - Zuniga A
FAU - McGuigan, C
AU  - McGuigan C
FAU - Dono, R
AU  - Dono R
FAU - Davidson, G
AU  - Davidson G
FAU - Chabanis, S
AU  - Chabanis S
FAU - Gibson, T
AU  - Gibson T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Fetal Proteins)
RN  - 0 (Formins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Body Patterning/*genetics
MH  - Evolution, Molecular
MH  - Extremities/*embryology
MH  - Fetal Proteins/chemistry/*genetics/physiology
MH  - Formins
MH  - Humans
MH  - Limb Deformities, Congenital/*genetics
MH  - Mice
MH  - Microfilament Proteins
MH  - Molecular Sequence Data
MH  - Morphogenesis/*genetics
MH  - *Multigene Family
MH  - Nuclear Proteins/chemistry/*genetics/physiology
MH  - Phylogeny
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Transcription Factors/genetics
RF  - 56
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - 10.1007/s004410051269 [doi]
PST - ppublish
SO  - Cell Tissue Res. 1999 Apr;296(1):85-93. doi: 10.1007/s004410051269.