PMID- 10199965
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190720
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 296
IP  - 1
DP  - 1999 Apr
TI  - T-box genes and the formation of vertebrate forelimb- and hindlimb specific
      pattern.
PG  - 57-66
AB  - Limb patterning is thought to be a multistep process involving specification of
      the limb fields, establishment of defined signaling centers that globally inform 
      cells of their position, interpretation of positional signals, and regulated
      growth and differentiation of the limb structures. Great progress has been made
      over the past few years in identifying the molecular players that control limb
      outgrowth and patterning, in particular, how the limb axes are specified.
      However, the molecular mechanism for determination of the morphological and
      functional differences between forelimbs and hindlimbs has remained elusive. The 
      recent identification of a series of limb-specific transcription factors has now 
      provided excellent candidates for such upstream regulators of limb identity, and 
      has allowed new insights into the regulatory network of making a hand or a foot.
FAU - Simon, H
AU  - Simon H
AD  - Department of Pediatrics, Northwestern University Medical School,
      CMIER-Developmental Systems Biology, 2300 Children's Plaza M/C 204, Chicago, IL
      60614, USA.hgsimon@nwu.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Avian Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (T-Box Domain Protein 2)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor 5)
RN  - 0 (TBX4 protein, Gallus gallus)
RN  - 0 (Tbx3 protein, mouse)
RN  - 0 (Tbx4 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Avian Proteins
MH  - *Body Patterning
MH  - Cell Differentiation
MH  - Chick Embryo
MH  - DNA-Binding Proteins/chemistry/*genetics/physiology
MH  - Embryonic and Fetal Development
MH  - Forelimb/*embryology
MH  - Hindlimb/*embryology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - *T-Box Domain Proteins
MH  - Transcription Factors/chemistry/genetics/physiology
MH  - Vertebrates/*embryology
RF  - 71
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - 10.1007/s004410051266 [doi]
PST - ppublish
SO  - Cell Tissue Res. 1999 Apr;296(1):57-66. doi: 10.1007/s004410051266.