PMID- 10199400
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 1
DP  - 1999 Apr 2
TI  - A Smad transcriptional corepressor.
PG  - 29-39
AB  - Following TGFbeta receptor-mediated phosphorylation and association with Smad4,
      Smad2 moves into the nucleus, binds to target promoters in association with
      DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate
      transcription. We identified the homeodomain protein TGIF as a Smad2-binding
      protein and a repressor of transcription. A TGFbeta-activated Smad complex can
      recruit TGIF and histone deacetylases (HDACs) to a Smad target promoter,
      repressing transcription. Thus, upon entering the nucleus, a Smad2-Smad4 complex 
      may interact with coactivators, forming a transcriptional activation complex, or 
      with TGIF and HDACs, forming a transcriptional repressor complex. Formation of
      one of these two mutually exclusive complexes is determined by the relative
      levels of Smad corepressors and coactivators within the cell.
FAU - Wotton, D
AU  - Wotton D
AD  - Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering
      Cancer Center, New York, New York 10021, USA.
FAU - Lo, R S
AU  - Lo RS
FAU - Lee, S
AU  - Lee S
FAU - Massague, J
AU  - Massague J
LA  - eng
GR  - CA34610/CA/NCI NIH HHS/United States
GR  - GM07739/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxh1 protein, mouse)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Smad2 Protein)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Animals
MH  - Binding, Competitive
MH  - COS Cells
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/metabolism/*physiology
MH  - Epithelial Cells
MH  - Forkhead Transcription Factors
MH  - Histone Deacetylases/metabolism/physiology
MH  - Homeodomain Proteins/*physiology
MH  - Lung
MH  - Macromolecular Substances
MH  - Mink
MH  - Nuclear Proteins/physiology
MH  - Repressor Proteins/*physiology
MH  - Signal Transduction
MH  - Smad2 Protein
MH  - Trans-Activators/genetics/metabolism/*physiology
MH  - Transcription Factors/physiology
MH  - Transcription, Genetic
MH  - Transforming Growth Factor beta/physiology
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - S0092-8674(00)80712-6 [pii]
AID - 10.1016/s0092-8674(00)80712-6 [doi]
PST - ppublish
SO  - Cell. 1999 Apr 2;97(1):29-39. doi: 10.1016/s0092-8674(00)80712-6.