PMID- 10198638
OWN - NLM
STAT- MEDLINE
DCOM- 19990426
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 3
IP  - 3
DP  - 1999 Mar
TI  - Identity between TRAP and SMCC complexes indicates novel pathways for the
      function of nuclear receptors and diverse mammalian activators.
PG  - 361-70
AB  - The human thyroid hormone receptor-associated protein (TRAP) complex, an earlier 
      described coactivator for nuclear receptors, and an SRB- and MED-containing
      cofactor complex (SMCC) that mediates activation by Gal4-p53 are shown to be
      virtually the same with respect to specific polypeptide subunits, coactivator
      functions, and mechanisms of action (activator interactions). In parallel with
      ligand-dependent interactions of nuclear receptors with the TRAP220 subunit, p53 
      and VP16 activation domains interact directly with a newly cloned TRAP80 subunit.
      These results indicate novel pathways for the function of nuclear receptors and
      other activators (p53 and VP16) through a common coactivator complex that is
      likely to target RNA polymerase II. Identification of the TRAP230 subunit as a
      previously predicted gene product also suggests a coactivator-related
      transcription defect in certain disease states.
FAU - Ito, M
AU  - Ito M
AD  - Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New
      York, New York 10021, USA.
FAU - Yuan, C X
AU  - Yuan CX
FAU - Malik, S
AU  - Malik S
FAU - Gu, W
AU  - Gu W
FAU - Fondell, J D
AU  - Fondell JD
FAU - Yamamura, S
AU  - Yamamura S
FAU - Fu, Z Y
AU  - Fu ZY
FAU - Zhang, X
AU  - Zhang X
FAU - Qin, J
AU  - Qin J
FAU - Roeder, R G
AU  - Roeder RG
LA  - eng
SI  - GENBANK/AF117657
SI  - GENBANK/AF117754
SI  - GENBANK/AF117755
SI  - GENBANK/AF117756
SI  - GENBANK/AF121228
SI  - GENBANK/AF135802
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Carrier Proteins)
RN  - 0 (Fungal Proteins)
RN  - 0 (Herpes Simplex Virus Protein Vmw65)
RN  - 0 (MED1 protein, human)
RN  - 0 (MED14 protein, human)
RN  - 0 (MED6 protein, human)
RN  - 0 (Med17 protein, human)
RN  - 0 (Mediator Complex)
RN  - 0 (Mediator Complex Subunit 1)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (SRB2 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.7.- (RNA Polymerase II)
SB  - IM
MH  - Amino Acid Sequence
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Carrier Proteins/chemistry/*genetics/*metabolism
MH  - Cloning, Molecular
MH  - Fungal Proteins/chemistry/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - HeLa Cells
MH  - Herpes Simplex Virus Protein Vmw65/metabolism
MH  - Humans
MH  - Mediator Complex
MH  - Mediator Complex Subunit 1
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - RNA Polymerase II/metabolism
MH  - Receptors, Calcitriol/metabolism
MH  - Receptors, Thyroid Hormone/*metabolism
MH  - Response Elements/genetics
MH  - *Saccharomyces cerevisiae Proteins
MH  - Trans-Activators/genetics/*metabolism
MH  - Transcription Factors/chemistry/genetics/*metabolism
MH  - Tumor Suppressor Protein p53/metabolism
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - S1097-2765(00)80463-3 [pii]
AID - 10.1016/s1097-2765(00)80463-3 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Mar;3(3):361-70. doi: 10.1016/s1097-2765(00)80463-3.