PMID- 10198169
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20101118
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 57
IP  - 2
DP  - 1999 Apr 15
TI  - Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for
      an ancient, large-scale duplication.
PG  - 289-92
AB  - The THRA gene encoding thyroid hormone receptor alpha shares an unusual partial
      overlap with the NR1D1 gene encoding the orphan receptor Rev-ErbAalpha. Though
      THRA and NR1D1 have close relatives in THRB and NR1D2, which encode TRbeta and
      Rev-ErbAbeta, these beta isoforms do not share an analogous overlap. Here we
      report that the human THRB and NR1D2 genes are separated by approximately 1 Mb on
      chromosome 3 and that these two genes are also linked to the RARB gene, which
      encodes retinoic acid receptor beta. Since previous results indicate that the
      THRA/NR1D1 locus is also linked to the RARA gene, these results suggest that the 
      two receptor gene clusters were generated by a single large-scale duplication.
CI  - Copyright 1999 Academic Press.
FAU - Koh, Y S
AU  - Koh YS
AD  - Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza,
      Houston, Texas 77030, USA.
FAU - Moore, D D
AU  - Moore DD
LA  - eng
GR  - DK43382/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
SB  - IM
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Contig Mapping
MH  - DNA-Binding Proteins/genetics
MH  - Gene Duplication
MH  - Genetic Linkage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Receptors, Retinoic Acid/genetics
MH  - Receptors, Thyroid Hormone/genetics
EDAT- 1999/04/13 00:00
MHDA- 1999/04/13 00:01
CRDT- 1999/04/13 00:00
PHST- 1999/04/13 00:00 [pubmed]
PHST- 1999/04/13 00:01 [medline]
PHST- 1999/04/13 00:00 [entrez]
AID - S0888-7543(98)95683-X [pii]
AID - 10.1006/geno.1998.5683 [doi]
PST - ppublish
SO  - Genomics. 1999 Apr 15;57(2):289-92. doi: 10.1006/geno.1998.5683.