PMID- 10197979
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190603
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 7
DP  - 1999 Apr 1
TI  - Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB
      factor.
PG  - 792-7
AB  - The induction of immunity genes in Drosophila has been proposed to be dependent
      on Dorsal, Dif, and Relish, the NF-kappaB-related factors. Here we provide
      genetic evidence that Dif is required for the induction of only a subset of
      antimicrobial peptide genes. The results show that the presence of Dif without
      Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also
      demonstrate that Dif is a downstream component of the Toll signaling pathway in
      activating the drosomycin expression. These results reveal that individual
      members of the NF-kappaB family in Drosophila have distinct roles in immunity and
      development.
FAU - Meng, X
AU  - Meng X
AD  - Program in Molecular Medicine, Department of Cell Biology, and Department of
      Biochemistry and Molecular Biology, University of Massachusetts Medical School,
      Worcester, Massachusetts 01605 USA.
FAU - Khanuja, B S
AU  - Khanuja BS
FAU - Ip, Y T
AU  - Ip YT
LA  - eng
GR  - R01 GM053269/GM/NIGMS NIH HHS/United States
GR  - GM53269/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Androgen-Binding Protein)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Defensins)
RN  - 0 (Dif protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Rel protein, Drosophila)
RN  - 0 (Ribosomal Proteins)
RN  - 0 (RpL32 protein, Drosophila)
RN  - 0 (Tl protein, Drosophila)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Transcription Factors)
RN  - 0 (probasin)
RN  - 159522-55-1 (DRS protein, Drosophila)
SB  - IM
MH  - Androgen-Binding Protein/genetics/metabolism
MH  - Animals
MH  - Anti-Bacterial Agents/metabolism
MH  - Blotting, Northern
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Defensins
MH  - Drosophila/*genetics/immunology
MH  - *Drosophila Proteins
MH  - Exons
MH  - Genes, Insect
MH  - Insect Proteins/*genetics/metabolism
MH  - Introns
MH  - Membrane Glycoproteins/*genetics/metabolism
MH  - Models, Genetic
MH  - NF-kappa B/genetics/metabolism
MH  - Proteins/metabolism
MH  - *Receptors, Cell Surface
MH  - *Ribosomal Proteins
MH  - Signal Transduction
MH  - Time Factors
MH  - Toll-Like Receptors
MH  - Transcription Factors/genetics/metabolism
PMC - PMC316597
EDAT- 1999/04/10 00:00
MHDA- 1999/04/10 00:01
CRDT- 1999/04/10 00:00
PHST- 1999/04/10 00:00 [pubmed]
PHST- 1999/04/10 00:01 [medline]
PHST- 1999/04/10 00:00 [entrez]
AID - 10.1101/gad.13.7.792 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Apr 1;13(7):792-7. doi: 10.1101/gad.13.7.792.