PMID- 10196374
OWN - NLM
STAT- MEDLINE
DCOM- 19990623
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 5
DP  - 1999 May
TI  - Zim1, a maternally expressed mouse Kruppel-type zinc-finger gene located in
      proximal chromosome 7.
PG  - 847-54
AB  - In analysis of a conserved region of proximal mouse chromosome 7 and human
      chromosome 19q, we have isolated a novel mouse gene, Zim1 (imprinted zinc-finger 
      gene 1), encoding a typical Kruppel-type (C2H2) zinc-finger protein, located
      within 30 kb of a known imprinted gene, Peg3 (paternally expressed gene 3). Our
      studies demonstrate that Zim1 is also imprinted; the gene is expressed mainly
      from the maternal allele and at high levels only during embryonic and neonatal
      stages. In contrast to most tissues, Zim1 is expressed biallelically in neonatal 
      and adult brain with slightly more input from the maternal allele. Zim1 produces 
      multiple transcripts that range in size from 7.5 to 15 kb. The 7.5 kb transcript 
      is expressed at highest levels and appears to be embryo specific. Whole mount in 
      situ hybridization analysis indicates that Zim1 is expressed at significant
      levels in the apical ectodermal ridge of the limb buds during embryogenesis,
      suggesting a potential role of Zim1 in limb formation. We have identified the
      potential human ortholog of Zim1 near PEG3 in a conserved, gene-rich region of
      human chromosome 19q13.4. The close juxtaposition of reciprocally imprinted genes
      has also been seen in other imprinted regions, such as human 11p15.5/Mmu7 ( H19 /
      Igf2 ) and suggests that the two genes may be co-regulated. These and other data 
      suggest the presence of an unexplored, conserved imprinted domain in human
      chromosome 19q13.4 and proximal Mmu7.
FAU - Kim, J
AU  - Kim J
AD  - Human Genome Center, Biology and Biotechnology Research Program, L-452, Lawrence 
      Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA.
      kim16@llnl.gov
FAU - Lu, X
AU  - Lu X
FAU - Stubbs, L
AU  - Stubbs L
LA  - eng
SI  - GENBANK/AF111101
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PEG3 protein, human)
RN  - 0 (Peg3 protein, mouse)
RN  - 0 (Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Zim1 protein, mouse)
RN  - EC 2.7.- (Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*genetics/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 19
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/genetics
MH  - Embryonic and Fetal Development/genetics
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - *Genomic Imprinting
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*genetics/metabolism
MH  - Physical Chromosome Mapping
MH  - *Protein Kinases
MH  - Proteins/genetics
MH  - *Repressor Proteins
MH  - Transcription Factors/genetics
MH  - Zinc Fingers/*genetics
EDAT- 1999/04/10 00:00
MHDA- 1999/04/10 00:01
CRDT- 1999/04/10 00:00
PHST- 1999/04/10 00:00 [pubmed]
PHST- 1999/04/10 00:01 [medline]
PHST- 1999/04/10 00:00 [entrez]
AID - ddc090 [pii]
AID - 10.1093/hmg/8.5.847 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 May;8(5):847-54. doi: 10.1093/hmg/8.5.847.