PMID- 10195896
OWN - NLM
STAT- MEDLINE
DCOM- 19990504
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5412
DP  - 1999 Apr 9
TI  - Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha
      subunit of IkappaB kinase.
PG  - 316-20
AB  - The oligomeric IkappaB kinase (IKK) is composed of three polypeptides: IKKalpha
      and IKKbeta, the catalytic subunits, and IKKgamma, a regulatory subunit. IKKalpha
      and IKKbeta are similar in structure and thought to have similar
      function-phosphorylation of the IkappaB inhibitors in response to proinflammatory
      stimuli. Such phosphorylation leads to degradation of IkappaB and activation of
      nuclear factor kappaB transcription factors. The physiological function of these 
      protein kinases was explored by analysis of IKKalpha-deficient mice. IKKalpha was
      not required for activation of IKK and degradation of IkappaB by proinflammatory 
      stimuli. Instead, loss of IKKalpha interfered with multiple morphogenetic events,
      including limb and skeletal patterning and proliferation and differentiation of
      epidermal keratinocytes.
FAU - Hu, Y
AU  - Hu Y
AD  - Department of Pharmacology, Cancer Center, University of California San Diego, La
      Jolla, CA 92093-0636, USA.
FAU - Baud, V
AU  - Baud V
FAU - Delhase, M
AU  - Delhase M
FAU - Zhang, P
AU  - Zhang P
FAU - Deerinck, T
AU  - Deerinck T
FAU - Ellisman, M
AU  - Ellisman M
FAU - Johnson, R
AU  - Johnson R
FAU - Karin, M
AU  - Karin M
LA  - eng
GR  - R01 AI43477/AI/NIAID NIH HHS/United States
GR  - R37 ES04151/ES/NIEHS NIH HHS/United States
GR  - RR04050/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (I-kappa B Proteins)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.10 (Chuk protein, mouse)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
RN  - EC 2.7.11.10 (Ikbkb protein, mouse)
RN  - EC 2.7.11.10 (Ikbke protein, mouse)
SB  - IM
CIN - Science. 1999 Apr 9;284(5412):271-3. PMID: 10232975
MH  - Abnormalities, Multiple/enzymology/genetics
MH  - Animals
MH  - Apoptosis
MH  - Body Patterning
MH  - Bone and Bones/abnormalities/embryology
MH  - Cell Differentiation
MH  - Cell Nucleus/metabolism
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/metabolism
MH  - Dimerization
MH  - *Embryonic and Fetal Development
MH  - Enzyme Activation
MH  - Epidermal Cells
MH  - Epidermis/embryology
MH  - Female
MH  - Gene Targeting
MH  - I-kappa B Kinase
MH  - I-kappa B Proteins
MH  - Keratinocytes
MH  - Limb Deformities, Congenital/enzymology
MH  - Male
MH  - Mice
MH  - *Morphogenesis
MH  - Mutation
MH  - Phosphorylation
MH  - Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism
MH  - Skin/embryology
MH  - Skin Abnormalities/enzymology
EDAT- 1999/04/09 00:00
MHDA- 1999/04/09 00:01
CRDT- 1999/04/09 00:00
PHST- 1999/04/09 00:00 [pubmed]
PHST- 1999/04/09 00:01 [medline]
PHST- 1999/04/09 00:00 [entrez]
AID - 10.1126/science.284.5412.316 [doi]
PST - ppublish
SO  - Science. 1999 Apr 9;284(5412):316-20. doi: 10.1126/science.284.5412.316.