PMID- 10194514
OWN - NLM
STAT- MEDLINE
DCOM- 19990609
LR  - 20191024
IS  - 0952-5041 (Print)
IS  - 0952-5041 (Linking)
VI  - 22
IP  - 2
DP  - 1999 Apr
TI  - The structure and function of the ATP-sensitive K+ channel in insulin-secreting
      pancreatic beta-cells.
PG  - 113-23
AB  - ATP-sensitive K+ channels (KATP channels) play important roles in many cellular
      functions by coupling cell metabolism to electrical activity. The KATP channels
      in pancreatic beta-cells are thought to be critical in the regulation of
      glucose-induced and sulfonylurea-induced insulin secretion. Until recently,
      however, the molecular structure of the KATP channel was not known. Cloning
      members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and 
      Kir6.2) and the sulfonylurea receptors (SUR1 and SUR2) has clarified the
      molecular structure of KATP channels. The pancreatic beta-cell KATP channel
      comprises two subunits: a Kir6.2 subunit and an SUR1 subunit. Molecular
      biological and molecular genetic studies have provided insights into the
      physiological and pathophysiological roles of the pancreatic beta-cell KATP
      channel in insulin secretion.
FAU - Miki, T
AU  - Miki T
AD  - Department of Molecular Medicine, Chiba University Graduate School of Medicine,
      1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan.
FAU - Nagashima, K
AU  - Nagashima K
FAU - Seino, S
AU  - Seino S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (ABCC8 protein, human)
RN  - 0 (ABCC9 protein, human)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Abcc8 protein, mouse)
RN  - 0 (Insulin)
RN  - 0 (Nucleotides)
RN  - 0 (Potassium Channels)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (Receptors, Drug)
RN  - 0 (Sulfonylurea Receptors)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - *ATP-Binding Cassette Transporters
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Cloning, Molecular
MH  - Humans
MH  - Hyperinsulinism/genetics/metabolism
MH  - Hypoglycemia/genetics/metabolism
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Islets of Langerhans/cytology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Mutation
MH  - Nucleotides/metabolism
MH  - Potassium Channels/*chemistry/genetics/*metabolism
MH  - *Potassium Channels, Inwardly Rectifying
MH  - Receptors, Drug/chemistry/genetics/metabolism
MH  - Sulfonylurea Receptors
RF  - 68
EDAT- 1999/04/09 00:00
MHDA- 1999/04/09 00:01
CRDT- 1999/04/09 00:00
PHST- 1999/04/09 00:00 [pubmed]
PHST- 1999/04/09 00:01 [medline]
PHST- 1999/04/09 00:00 [entrez]
AID - 10.1677/jme.0.0220113 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 1999 Apr;22(2):113-23. doi: 10.1677/jme.0.0220113.