PMID- 10191291
OWN - NLM
STAT- MEDLINE
DCOM- 19990503
LR  - 20210217
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 40
IP  - 4
DP  - 1999 Apr
TI  - Characterization of phosphomevalonate kinase: chromosomal localization,
      regulation, and subcellular targeting.
PG  - 672-9
AB  - Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to
      mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In
      this study we have localized the phosphomevalonate kinase gene to chromosome
      1p13-1q22-23 and present a genomic map indicating that the gene spans more than
      8.4 kb in the human genome. Furthermore, we show that message levels and enzyme
      activity of rat liver phosphomevalonate kinase are regulated in response to
      dietary sterol levels and that this regulation is coordinate with
      3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of
      cholesterol biosynthesis. In addition, we demonstrate that phosphomevalonate
      kinase is a peroxisomal protein which requires the C-terminal peroxisomal
      targeting signal, Ser-Arg-Leu, for localization to the organelle.
FAU - Olivier, L M
AU  - Olivier LM
AD  - Department of Biology, San Diego State University, San Diego, CA 92182, USA.
FAU - Chambliss, K L
AU  - Chambliss KL
FAU - Gibson, K M
AU  - Gibson KM
FAU - Krisans, S K
AU  - Krisans SK
LA  - eng
SI  - GENBANK/AF026069
GR  - DK32852/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Protein Sorting Signals)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sterols)
RN  - EC 2.7.4.- (Phosphotransferases (Phosphate Group Acceptor))
RN  - EC 2.7.4.2 (phosphomevalonate kinase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 1
MH  - *Gene Expression Regulation, Enzymologic/drug effects
MH  - Gene Targeting
MH  - Humans
MH  - Liver/enzymology/*ultrastructure
MH  - Male
MH  - Microbodies/enzymology
MH  - Molecular Sequence Data
MH  - Phosphotransferases (Phosphate Group Acceptor)/chemistry/*genetics/metabolism
MH  - Protein Sorting Signals/chemistry
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sequence Alignment
MH  - Sterols/administration & dosage
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
AID - S0022-2275(20)32146-5 [pii]
PST - ppublish
SO  - J Lipid Res. 1999 Apr;40(4):672-9.