PMID- 10191088
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 57
IP  - 1
DP  - 1999 Apr 1
TI  - Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid
      germ cells.
PG  - 94-101
AB  - Through the preparation of a subtracted cDNA library, we have extensively
      isolated genes whose expression is induced in mouse spermatogenic cells. One of
      the genes encoded a protein with a RING zinc-finger motif, which we termed
      sperizin (spermatid-specific ring zinc finger). Transcription of the sperizin
      gene was not observed in prepubertal testis, but became detectable at day 23.
      Northern and in situ hybridization analyses indicated that the sperizin gene was 
      exclusively expressed in the round spermatid. The sperizin gene is intronless,
      and GFP-tagged sperizin was found to be localized in the cytoplasm of ectopically
      expressed somatic cultured cells. We assigned the chromosomal localization of the
      sperizin gene to chromosome 17 using an interspecific backcross mapping panel.
      The data suggest that we have identified a new member of the RING-finger family
      of proteins that may be involved in spermatogenesis.
CI  - Copyright 1999 Academic Press.
FAU - Fujii, T
AU  - Fujii T
AD  - Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka,
      Suita, 565, Japan.
FAU - Tamura, K
AU  - Tamura K
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Yomogida, K
AU  - Yomogida K
FAU - Tanaka, H
AU  - Tanaka H
FAU - Nishimune, Y
AU  - Nishimune Y
FAU - Nojima, H
AU  - Nojima H
FAU - Abiko, Y
AU  - Abiko Y
LA  - eng
SI  - GENBANK/AB016984
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Znrf4 protein, mouse)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Cell Fractionation
MH  - Chromosome Mapping
MH  - Crosses, Genetic
MH  - DNA-Binding Proteins/*physiology
MH  - Gene Library
MH  - Germ Cells/*metabolism
MH  - Green Fluorescent Proteins
MH  - Haploidy
MH  - HeLa Cells
MH  - Humans
MH  - In Situ Hybridization
MH  - Inbreeding
MH  - Introns
MH  - Luminescent Proteins/metabolism
MH  - Male
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Spermatogenesis/physiology
MH  - Testis/anatomy & histology/physiology
MH  - Up-Regulation
MH  - Zinc Fingers/*physiology
EDAT- 1999/04/07 00:00
MHDA- 1999/04/07 00:01
CRDT- 1999/04/07 00:00
PHST- 1999/04/07 00:00 [pubmed]
PHST- 1999/04/07 00:01 [medline]
PHST- 1999/04/07 00:00 [entrez]
AID - S0888-7543(98)95738-X [pii]
AID - 10.1006/geno.1998.5738 [doi]
PST - ppublish
SO  - Genomics. 1999 Apr 1;57(1):94-101. doi: 10.1006/geno.1998.5738.