PMID- 10187783
OWN - NLM
STAT- MEDLINE
DCOM- 19990503
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 15
DP  - 1999 Apr 9
TI  - NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine
      kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase
      signaling pathway.
PG  - 10047-52
AB  - As part of a program to further understand the mechanism by which extracellular
      signals are coordinated and cell-specific outcomes are generated, we have cloned 
      a novel class of related adaptor molecules (NSP1, NSP2, and NSP3) and have
      characterized in more detail one of the members, NSP1. NSP1 has an Shc-related
      SH2 domain and a putative proline/serine-rich SH3 interaction domain. Treatment
      of cells with epidermal growth factor or insulin leads to NSP1 phosphorylation
      and increased association with a hypophosphorylated adaptor protein, p130(Cas).
      In contrast, cell contact with fibronectin results in Cas phosphorylation and a
      transient dissociation of NSP1 from p130(Cas). Increased expression of NSP1 in
      293 cells induces activation of JNK1, but not of ERK2. Consistent with this
      observation, NSP1 increases the activity of an AP-1-containing promoter. Thus, we
      have described a novel family of adaptor proteins, one of which may be involved
      in the process by which receptor tyrosine kinase and integrin receptors control
      the c-Jun N-terminal kinase/stress-activated protein kinase pathway.
FAU - Lu, Y
AU  - Lu Y
AD  - Department of Endocrine Research, Genentech, Inc., South San Francisco,
      California 94080, USA.
FAU - Brush, J
AU  - Brush J
FAU - Stewart, T A
AU  - Stewart TA
LA  - eng
SI  - GENBANK/AF124249
SI  - GENBANK/AF124250
SI  - GENBANK/AF124251
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (BCAR3 protein, human)
RN  - 0 (Crk-Associated Substrate Protein)
RN  - 0 (Growth Substances)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Insulin)
RN  - 0 (Integrins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (Retinoblastoma-Like Protein p130)
RN  - 0 (SH2D3A protein, human)
RN  - 0 (SH2D3C protein, human)
RN  - 0 (Transcription Factor AP-1)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinase 1)
RN  - EC 2.7.11.25 (MAP3K1 protein, human)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - COS Cells
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*physiology
MH  - Cloning, Molecular
MH  - Crk-Associated Substrate Protein
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Enzyme Activation
MH  - Epidermal Growth Factor/metabolism
MH  - ErbB Receptors/metabolism
MH  - *Expressed Sequence Tags
MH  - Growth Substances/*physiology
MH  - Guanine Nucleotide Exchange Factors
MH  - Insulin/metabolism
MH  - Integrins/*physiology
MH  - JNK Mitogen-Activated Protein Kinases
MH  - *MAP Kinase Kinase Kinase 1
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - Phosphoproteins/metabolism
MH  - Protein-Serine-Threonine Kinases/metabolism
MH  - Proteins/*genetics/metabolism
MH  - Retinoblastoma-Like Protein p130
MH  - *Signal Transduction
MH  - Transcription Factor AP-1/metabolism
EDAT- 1999/04/03 00:00
MHDA- 1999/04/03 00:01
CRDT- 1999/04/03 00:00
PHST- 1999/04/03 00:00 [pubmed]
PHST- 1999/04/03 00:01 [medline]
PHST- 1999/04/03 00:00 [entrez]
AID - 10.1074/jbc.274.15.10047 [doi]
AID - S0021-9258(19)73681-3 [pii]
PST - ppublish
SO  - J Biol Chem. 1999 Apr 9;274(15):10047-52. doi: 10.1074/jbc.274.15.10047.